Western Blot (WB)
(Western Blot: Sample: Human Serum; Primary Ab: 1ug/ml Rabbit Anti-Human MRE11A Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Rabbit anti-Human Meiotic Recombination 11 Homolog A Polyclonal Antibody | anti-MRE11A antibody
Polyclonal Antibody to Meiotic Recombination 11 Homolog A (MRE11A)
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Human Serum; Primary Ab: 1ug/ml Rabbit Anti-Human MRE11A Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Human Serum; Primary Ab: 1ug/ml Rabbit Anti-Human MRE11A Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded Kidney tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded Kidney tissue))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.
Protein type: Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease
Chromosomal Location of Human Ortholog: 11q21
Cellular Component: chromosome, telomeric region; cytoplasm; cytosol; Mre11 complex; nuclear chromosome, telomeric region; nucleoplasm; nucleus; PML body
Molecular Function: 3'-5' exonuclease activity; ATP-dependent DNA helicase activity; cadherin binding; DNA binding; double-stranded DNA binding; endodeoxyribonuclease activity; identical protein binding; manganese ion binding; nuclease activity; protein binding; protein C-terminus binding; single-stranded DNA endodeoxyribonuclease activity
Biological Process: cell proliferation; cellular response to DNA damage stimulus; DNA double-strand break processing; DNA duplex unwinding; DNA recombination; DNA repair; DNA replication; DNA synthesis involved in DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; intra-S DNA damage checkpoint; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of apoptosis; negative regulation of DNA endoreduplication; nucleic acid phosphodiester bond hydrolysis; positive regulation of interferon type I production; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; reciprocal meiotic recombination; regulation of mitotic recombination; sister chromatid cohesion; strand displacement; synapsis; telomere maintenance via telomerase; telomeric 3' overhang formation; viral process
Disease: Ataxia-telangiectasia-like Disorder 1
Research Articles on MRE11A
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Product Notes
The MRE11A mre11 (Catalog #AAA2028594) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Meiotic Recombination 11 Homolog A (MRE11A) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Meiotic Recombination 11 Homolog A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.2-2ug/mL;1:250-2500 Immunohistochemistry: 5-20ug/mL;1:25-100 Immunocytochemistry: 5-20ug/mL;1:25-100 Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the MRE11A mre11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Meiotic Recombination 11 Homolog A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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