Western Blot (WB)
(Western Blot: Sample: Rat Lymph Node Tissue.)
Rabbit anti-Human Lipase Polyclonal Antibody | anti-LIPD antibody
Polyclonal Antibody to Lipase, Lipoprotein (LIPD)
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Rat Lymph Node Tissue.)
Western Blot (WB)
(Western Blot: Sample: Rat Lymph Node Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant LIPD, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant LIPD, Human.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Brain tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Brain tissue))
NCBI and Uniprot Product Information
NCBI Description
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]
Uniprot Description
LPL: The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium. Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency); also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis. Belongs to the AB hydrolase superfamily. Lipase family.
Protein type: EC 3.1.1.34; Lipid Metabolism - glycerolipid; Membrane protein, GPI anchor; Phospholipase
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: cell surface; chylomicron; extracellular matrix; extracellular region; extracellular space; plasma membrane
Molecular Function: apolipoprotein binding; heparin binding; lipoprotein lipase activity; phospholipase activity; protein binding; receptor binding; triacylglycerol lipase activity; triglyceride binding
Biological Process: cholesterol homeostasis; fatty acid biosynthetic process; low density lipoprotein mediated signaling; phospholipid metabolic process; positive regulation of inflammatory response; regulation of lipoprotein lipase activity; response to cold; response to drug; response to glucose stimulus; retinoid metabolic process; triacylglycerol biosynthetic process; triacylglycerol metabolic process; triglyceride catabolic process
Disease: Hyperlipidemia, Familial Combined; Hyperlipoproteinemia, Type I
Research Articles on LIPD
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Product Notes
The LIPD lpl (Catalog #AAA2028518) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Lipase, Lipoprotein (LIPD) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Lipase can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 1-5ug/ml Immunocytochemistry in formalin fixed cells: 5-20ug/ml Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml Immunohistochemistry in paraffin section: 5-20ug/ml Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the LIPD lpl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Lipase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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