MGHHHHHHSGSEF-DGQCICED GFTGSDCAEL SCPGDCHGHG RCVNGQCICH EGFTGXDCKE QRCPSDCHGQ GRCEDGQCIC HEGFTGLDCG QRSCPNDCSN QGQCVAGRCI CNEGYTGVDC S
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
NCBI and Uniprot Product Information
NCBI Description
extracellular matrix glycoprotein; inhibits the attachment of fibroblasts to adhesive proteins [RGD, Feb 2006]
Uniprot Description
TNC: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Belongs to the tenascin family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted
Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; focal adhesion; membrane; extracellular region; basement membrane
Molecular Function: syndecan binding
Biological Process: osteoblast differentiation; response to ethanol; wound healing; response to mechanical stimulus; positive regulation of cell proliferation; response to wounding; negative regulation of cell adhesion; axon regeneration in the peripheral nervous system; neuromuscular junction development; neurite development; odontogenesis of dentine-containing teeth