Rabbit anti-Mouse Monoamine Oxidase A (MAOA) Polyclonal Antibody | anti-MAOA antibody

Polyclonal Antibody to Monoamine Oxidase A (MAOA)

Cat. Num. AAA2006929

• Gene Names: Maoa; AA407771; 1110061B18Rik
• Reactivity: Mouse
• Applications: Immunocytochemistry, Immunohistochemistry, ELISA, Western Blot
• Purity: Affinity Chromatography
• Synonyms: Monoamine Oxidase A (MAOA); Polyclonal Antibody; Polyclonal Antibody to Monoamine Oxidase A (MAOA); anti-MAOA antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Specificity: The antibody is a rabbit polyclonal antibody raised against MAOA. It has been selected for its ability to recognize MAOA in immunohistochemical staining andwestern blotting.
• Purity/Purification: Affinity Chromatography
• Form/Format: Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
• Concentration: 500ug/mL (varies by lot)
• Sequence: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.; MGHHHHHHSGSEF- QI MVLLGDKVKL SSPVTYIDQT DDNIIIETLN HEHYECKYVI SAIPPVLTAK IHFKPELPPE RNQLIQRLPM GAVIKCMVYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSMPAIM GFILARKAER LAKLHKDIRK RKICELYAKV LGSQEALSPV HYEEKNWCEE QYSGGCYTAY FPPGIMTLYG RVIRQPVG
• Sequence Length: 27

• Applicable Applications for anti-MAOA antibody: Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
• Application Notes: Western blotting: 1:100-400; Immunocytochemistry in formalin fixed cells: 1:100-500; Immunohistochemistry in formalin fixed frozen section: 1:100-500; Immunohistochemistry in paraffin section: 1:50-200; Enzyme-linked Immunosorbent Assay: 1:100-200
• Immunogen: Recombinant MAOA (Gln229~Gly428) expressed in E.coli.
• Cross Reactivity: Mouse
• Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2061003
• Preparation and Storage: Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Western Blot (WB)

(Western Blot: Sample: Recombinant MAOA, Mouse.)

Immunohistochemistry (IHC)

(DAB staining on IHC-P; Samples: Mouse Stomach Tissue)

Immunohistochemistry (IHC)

(DAB staining on IHC-P; Samples: Mouse Large Intestine Tissue.)

Immunohistochemistry (IHC)

(DAB staining on IHC-P; Samples: Mouse Spleen Tissue.)

Immunohistochemistry (IHC)

(DAB staining on IHC-P; Samples: Mouse Liver Tissue.)

NCBI and Uniprot Product Information

• NCBI GI #: 255759902
• NCBI GeneID: 17161
• NCBI Accession #: NP_776101.3
• NCBI GenBank Nucleotide #: NM_173740.3
• UniProt Accession #: Q64133; Q8K0Z8; B1AX52
• Molecular Weight: 59,602 Da
• NCBI Official Full Name: amine oxidase
• NCBI Official Synonym Full Names: monoamine oxidase A
• NCBI Official Symbol: Maoa
• NCBI Official Synonym Symbols: AA407771; 1110061B18Rik
• NCBI Protein Information: amine oxidase [flavin-containing] A
• UniProt Protein Name: Amine oxidase [flavin-containing] A
• Protein Family: Amine oxidase
• UniProt Gene Name: Maoa
• UniProt Synonym Gene Names: MAO-A

Uniprot Description

MAOA: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family.

Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - tyrosine; EC 1.4.3.4; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: X A1.2|X 11.78 cM

Cellular Component: integral component of membrane; membrane; mitochondrial outer membrane; mitochondrion

Molecular Function: amine oxidase activity; FAD binding; oxidoreductase activity; protein binding; serotonin binding

Biological Process: catecholamine metabolic process; dopamine catabolic process; neurotransmitter catabolic process; phenylethylamine metabolic process; serotonin metabolic process