Mouse Estrogen Receptor Alpha Monoclonal Antibody | anti-ESR1 antibody
Estrogen Receptor- alpha Monoclonal Antibody
Gene Names
ESR1; ER; ESR; Era; ESRA; NR3A1; DKFZp686N23123
Applications
Immunoblot, Western Blot, Immunoprecipitation
Synonyms
Estrogen Receptor Alpha; Monoclonal Antibody; Estrogen Receptor- alpha Monoclonal Antibody; Anti-Estrogen Receptor Alpha; Estrogen Receptor-alpha; anti-ESR1 antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG1 kappa
Specificity
Anti-Estrogen Receptor Alpha [Murine MAb to fusion protein corresponding to aa 1-190 of human estrogen receptor-alpha, a member of the steroid family of nuclear receptors.]
This antibody recognizes human ER- alpha , a 65 kD protein and a member of the steroid family of nuclear receptors. ER- alpha is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change that allows dimerization and binding to estrogen response element sequences. When bound to DNA, ER- alpha can positively or negatively regulate gene transcription.
This antibody recognizes human ER- alpha , a 65 kD protein and a member of the steroid family of nuclear receptors. ER- alpha is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change that allows dimerization and binding to estrogen response element sequences. When bound to DNA, ER- alpha can positively or negatively regulate gene transcription.
Form/Format
100 ug Protein G-purified antibody in PBS, pH 7.4
Sequence Length
20
Applicable Applications for anti-ESR1 antibody
Immunoblot, Immunoprecipitation
Application Notes
Immunoblotting: use at 1-5 ug/ml.
Immunoprecipitation: use at 1-5 ug/ml.
Positive controls: MCF-7 cells andrecombinant protein.
Immunoprecipitation: use at 1-5 ug/ml.
Positive controls: MCF-7 cells andrecombinant protein.
Antigen
6-His fusion proteincontaining the region encoding aa 1-190of human estrogen receptor- alpha (ER- alpha ) expressed in E. coli.
Stabilizer
None
Preservatives
None. Available on request.
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
This antibody is stable for at least one (1) year at -70 degree C. Avoid multiple freeze thaw cycles.
Product Categories/Family for anti-ESR1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
2,203 Da
NCBI Official Full Name
estrogen receptor alpha
NCBI Official Synonym Full Names
estrogen receptor 1
NCBI Official Symbol
ESR1
NCBI Official Synonym Symbols
ER; ESR; Era; ESRA; NR3A1; DKFZp686N23123
NCBI Protein Information
estrogen receptor; ER-alpha; OTTHUMP00000017718; OTTHUMP00000017719; estradiol receptor; estrogen receptor alpha delta 4 +49 isoform; nuclear receptor subfamily 3 group A member 1; estrogen receptor alpha delta 4*,5,6,7*/654 isoform; estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform
UniProt Protein Name
Putative uncharacterized protein
Protein Family
UniProt Entry Name
A0A4R1_HUMAN
NCBI Description
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq]
Research Articles on ESR1
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Product Notes
The ESR1 (Catalog #AAA190147) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Estrogen Receptor Alpha can be used in a range of immunoassay formats including, but not limited to, Immunoblot, Immunoprecipitation. Immunoblotting: use at 1-5 ug/ml. Immunoprecipitation: use at 1-5 ug/ml. Positive controls: MCF-7 cells andrecombinant protein. Researchers should empirically determine the suitability of the ESR1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Estrogen Receptor Alpha, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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