Arc Polyclonal Antibody | anti-ARC antibody
Anti-Arc Antibody
Western Blot (WB)
(Anti- Arc Picoband antibody, MBS177684, Western blottingAll lanes: Anti Arc (MBS177684) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Rat Testis Tissue Lysate at 50ugLane 3: Mouse Brain Tissue Lysate at 50ugLane 4: PANC Whole Cell Lysate at 40ugLane 5: HELA Whole Cell Lysate at 40ugLane 6: MCF-7 Whole Cell Lysate at 40ugPredicted bind size: 45KDObserved bind size: 45KD )
Background: ARC, officially called activity-regulated cytoskeleton-associated protein, is a plasticity protein first characterized in 1995. It is a member of the immediate-early gene (IEG) family. The ARC gene is mapped to chromosome 8q24. It has got 460 amino acid protein which shares significant similarity with rat Arc. The Arc is highly expressed in heart, brain, lung, skeletal muscle, pancreas, prostate and testis and has got weak expression in small intestine, colon, and peripheral blood leukocytes. Arc is widely considered to be an important protein in neurobiology and also a significant tool for systems neuroscience.
NCBI and Uniprot Product Information
Uniprot Description
ARG3.1: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. Belongs to the ARC/ARG3.1 family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: acrosome; actin cytoskeleton; cell junction; cytoplasm; dendritic spine; endosome; plasma membrane; postsynaptic density; postsynaptic membrane
Biological Process: anterior/posterior pattern formation; cell migration; cytoskeleton organization and biogenesis; endocytosis; endoderm development; learning; regulation of cell morphogenesis; regulation of neuronal synaptic plasticity