Testing Data
(Anti-CTNNA1 Picoband antibody, MBS177486-1.jpgAll lanes: Anti CTNNA1 (MBS177486) at 0.5ug/mlWB: Human Recombinant CTNNA1 Protein 0.5ngPredicted bind size: 47KDObserved bind size: 47KD )
Rabbit Catenin alpha-1 Polyclonal Antibody | anti-CTNNA1 antibody
Anti-CTNNA1 Antibody
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human, Mouse, Rat
Immunohistochemistry (Frozen Section): Concentration: 0.5-1mug/ml; Tested Species: Rat
Testing Data
(Anti-CTNNA1 Picoband antibody, MBS177486-1.jpgAll lanes: Anti CTNNA1 (MBS177486) at 0.5ug/mlWB: Human Recombinant CTNNA1 Protein 0.5ngPredicted bind size: 47KDObserved bind size: 47KD )
Testing Data
(Anti-CTNNA1 Picoband antibody, MBS177486-1.jpgAll lanes: Anti CTNNA1 (MBS177486) at 0.5ug/mlWB: Human Recombinant CTNNA1 Protein 0.5ngPredicted bind size: 47KDObserved bind size: 47KD )
Testing Data
(Anti-CTNNA1 Picoband antibody, MBS177486-2.jpgAll lanes: Anti CTNNA1 (MBS177486) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Rat Lung Tissue Lysate at 50ugLane 3: Rat Cardiac Muscle Tissue Lysate at 50ugLane 4: NIH3T3 Whole Cell Lysate at 40ugLane 5: PC-12 Whole Cell Lysate at 40ugLane 6: HEPG2 Whole Cell Lysate at 40ugLane 7: HELA Whole Cell Lysate at 40ugLane 8: MCF-7 Whole Cell Lysate at 40ugLane 9: HEPA Whole Cell Lysate at 40ugPredicted bind size: 100KDObserved bind size: 100KD )
Testing Data
(Anti-CTNNA1 Picoband antibody, MBS177486-2.jpgAll lanes: Anti CTNNA1 (MBS177486) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Rat Lung Tissue Lysate at 50ugLane 3: Rat Cardiac Muscle Tissue Lysate at 50ugLane 4: NIH3T3 Whole Cell Lysate at 40ugLane 5: PC-12 Whole Cell Lysate at 40ugLane 6: HEPG2 Whole Cell Lysate at 40ugLane 7: HELA Whole Cell Lysate at 40ugLane 8: MCF-7 Whole Cell Lysate at 40ugLane 9: HEPA Whole Cell Lysate at 40ugPredicted bind size: 100KDObserved bind size: 100KD )
Immunohistochemistry (IHC)
(Anti-CTNNA1 Picoband antibody, MBS177486-3.JPGIHC(P): Rat Intestine Tissue )
Immunohistochemistry (IHC)
(Anti-CTNNA1 Picoband antibody, MBS177486-3.JPGIHC(P): Rat Intestine Tissue )
Immunohistochemistry (IHC)
(Anti-CTNNA1 Picoband antibody, MBS177486-4.JPGIHC(P): Human Mammary Tissue )
Immunohistochemistry (IHC)
(Anti-CTNNA1 Picoband antibody, MBS177486-4.JPGIHC(P): Human Mammary Tissue )
Immunohistochemistry (IHC)
(Anti-CTNNA1 Picoband antibody, MBS177486-5.JPGIHC(P): Mouse Intestine Tissue )
Immunohistochemistry (IHC)
(Anti-CTNNA1 Picoband antibody, MBS177486-5.JPGIHC(P): Mouse Intestine Tissue )
Background: CTNNA1, also known as Catenin alpha-1 or Catenin (cadherin-associated protein), alpha 1, is a protein that in humans is encoded by the CTNNA1 gene. It is mapped to 5q31.2. When surface epithelium CTNNA1 was ablated, hair follicle development was blocked and epidermal morphogenesis was dramatically affected, with defects in adherens junction formation, intercellular adhesion, and epithelial polarity. In vitro, CTNNA1 null keratinocytes were poorly contact inhibited and grew rapidly. These differences were not dependent upon intercellular adhesion and were in marked contrast to keratinocytes conditionally null for another essential intercellular adhesion protein, desmoplakin Knockout keratinocytes exhibited sustained activation of the Ras-MAPK cascade due to aberrations in growth factor responses. It is concluded that features of precancerous lesions often attributed to defects in cell cycle regulatory genes can be generated by compromising the function of CTNNA1.
NCBI and Uniprot Product Information
Uniprot Description
CTNNA1: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin. Binds MLLT4 and F-actin. Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 and beta-catenin/CTNNB1 or gamma- catenin/JUP; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F- actin by other proteins such as LIMA1. Interacts with ARHGAP21 and with AJUBA. Interacts with LIMA1. Expressed ubiquitously in normal tissues. Belongs to the vinculin/alpha-catenin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Actin-binding
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: focal adhesion; lamellipodium; acrosome; plasma membrane; intercellular junction; zonula adherens; catenin complex; cytosol; actin cytoskeleton
Molecular Function: actin filament binding; protein binding; cadherin binding; gamma-catenin binding; beta-catenin binding; structural molecule activity; vinculin binding
Biological Process: intercellular junction assembly and maintenance; apical junction assembly; gap junction assembly; protein heterooligomerization; axon regeneration; male gonad development; establishment and/or maintenance of cell polarity; actin filament organization; odontogenesis of dentine-containing teeth; muscle cell differentiation; ovarian follicle development; negative regulation of neuroblast proliferation; response to estrogen stimulus; positive regulation of muscle cell differentiation; positive regulation of smoothened signaling pathway; cell adhesion; vascular endothelial growth factor receptor signaling pathway; aging
Research Articles on CTNNA1
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Product Notes
The CTNNA1 ctnna1 (Catalog #AAA177486) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CTNNA1 Antibody reacts with Human, Mouse, Rat. No cross reactivity with other proteins. and may cross-react with other species as described in the data sheet. AAA Biotech's Catenin alpha-1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-F). Western Blot: Concentration: 0.1-0.5mug/ml; Tested Species: Human, Rat Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human, Mouse, Rat Immunohistochemistry (Frozen Section): Concentration: 0.5-1mug/ml; Tested Species: Rat. Researchers should empirically determine the suitability of the CTNNA1 ctnna1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Catenin alpha-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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