Western Blot (WB)
(Anti-RIP3 antibody, MBS176800, Western blottingLane 1: PANC Cell LysateLane 2: SW620 Cell LysateLane 3: SKOV-3 Cell LysateLane 4: M231 Cell Lysate )
Rabbit anti-Human RIP3 Polyclonal Antibody | anti-RIPK3 antibody
Anti-RIP3 antibody
Western Blot (WB)
(Anti-RIP3 antibody, MBS176800, Western blottingLane 1: PANC Cell LysateLane 2: SW620 Cell LysateLane 3: SKOV-3 Cell LysateLane 4: M231 Cell Lysate )
Western Blot (WB)
(Anti-RIP3 antibody, MBS176800, Western blottingLane 1: PANC Cell LysateLane 2: SW620 Cell LysateLane 3: SKOV-3 Cell LysateLane 4: M231 Cell Lysate )
Background: Receptor-interacting serine/threonine-protein kinase 3(RIPK3), also known as RIP3 is an enzyme that in humans is encoded by the RIPK3 gene. This gene is mapped to 14q12. The product of this gene is a member of the receptor-interacting protein(RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor(TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.
NCBI and Uniprot Product Information
NCBI Description
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
Uniprot Description
RIPK3: Promotes apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.11.1; Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); TKL group; RIPK family
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: mitochondrion; plasma membrane; cytosol
Molecular Function: NF-kappaB-inducing kinase activity; protein serine/threonine kinase activity; identical protein binding; protein binding; transcription coactivator activity; protein complex binding; ATP binding; protein kinase activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; protein heterooligomerization; protein amino acid autophosphorylation; T cell differentiation in the thymus; toll-like receptor 3 signaling pathway; signal transduction; activation of NF-kappaB transcription factor; regulation of T cell mediated cytotoxicity; regulation of adaptive immune response; positive regulation of interferon type I production; T cell homeostasis; positive regulation of ligase activity; toll-like receptor 4 signaling pathway; protein homooligomerization; positive regulation of oxidoreductase activity; spleen development; regulation of activated T cell proliferation; thymus development; MyD88-independent toll-like receptor signaling pathway; protein modification process; lymph node development; regulation of interferon-gamma production; toll-like receptor signaling pathway; activation of protein kinase activity; innate immune response
Research Articles on RIPK3
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Product Notes
The RIPK3 ripk3 (Catalog #AAA176800) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-RIP3 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RIP3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the RIPK3 ripk3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RIP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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