Western Blot (WB)
(Anti-Aquaporin 10 antibody, MBS176225, Western blottingWB: COLO320 Cell Lysate )
Rabbit anti-Human Aquaporin 10 Polyclonal Antibody | anti-AQP10 antibody
Anti-Aquaporin 10 antibody
Western Blot (WB)
(Anti-Aquaporin 10 antibody, MBS176225, Western blottingWB: COLO320 Cell Lysate )
Western Blot (WB)
(Anti-Aquaporin 10 antibody, MBS176225, Western blottingWB: COLO320 Cell Lysate )
Background: AQP10 was identified in human small intestine. This gene encoded a 264-amino-acid protein with high sequence identity with AQP3(53%), 9(52%), and 7(43%). These AQPs constitute one subfamily of AQP family that is differentiated from the other subfamily of AQP(AQP0, 1, 2, 4, 5, 6, and 8) by sequence homology. Northern blot analysis revealed expression of a 2.3-kb AQP10 transcript in jejunum but not liver. RNase protection analysis detected nearly exclusive expression in duodenum and jejunum. In situ hybridization analysis demonstrated highest expression of AQP10 in absorptive epithelial cells at the tips of villi in the jejunum. SDS-PAGE analysis showed expression of a 28-kD AQP10 protein, similar to its predicted size as well as to that of the other AQPs. Functional analysis indicated that cells expressing AQP10 are permeable to relatively low amounts of water, but, unlike AQP3, AQP7, and AQP9, are not permeable to urea or glycerol.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008]
Uniprot Description
AQP10: Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol. Belongs to the MIP/aquaporin (TC 1.A.8) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, aquaporin family; Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: urea transmembrane transporter activity; water channel activity; glycerol channel activity
Biological Process: glycerol transport; cellular water homeostasis; response to toxin; water transport; transmembrane transport
Research Articles on AQP10
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Product Notes
The AQP10 aqp10 (Catalog #AAA176225) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Aquaporin 10 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Aquaporin 10 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the AQP10 aqp10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Aquaporin 10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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