Rabbit anti-Human Kallikrein 2 Polyclonal Antibody | anti-KLK2 antibody
Anti-Kallikrein 2 antibody
Immunohistochemistry (IHC)
(Anti-Kallikrein 2 antibody, MBS175260, IHC(P)IHC(P): Human Prostatic Cancer Tissue )
Background: KLK2(KALLIKREIN 2), also called GLANDULAR or PROSTATIC, is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue. The KLK2 is a member of glandular kallikrein gene family that comprises 25 to 30 highly homologous genes that encode specific proteases involved in the processing of biologically active peptides. The KLK2 gene is mapped to 19q13.33. And the KLK2 gene contains 5 exons. An alternative KLK2 transcript, which they call KLK2-linked molecule(KLM), that arises from the use of an alternate donor site within intron 1. KLM shares only the N-terminal 15-amino acid signal peptide with the original KLK2 protein; the mature proteins display no similarity.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
Uniprot Description
KLK2: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.21.35
Chromosomal Location of Human Ortholog: 19q13.41
Cellular Component: extracellular region
Molecular Function: serine-type endopeptidase activity
Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis