Retinol Binding Protein 4 Protein | RBP4 protein
Retinol Binding Protein 4 (RBP4), Human Plasma
Custom preparations, technical support, bulk quantities and aliquoting available.
Human Retinol binding protein (RBP) is responsible for binding and transporting retinol (vitamin A). Human RBP has a binding site for one molecule of retinol and circulates in the plasma together with prealbumin in the form of a protein complex in a molar ratio of 1:1. This binding to prealbumin prevents greater glomerular losses of the human retinol-binding protein. Only the retinol-free form of the retinol-binding protein, which has no affinity for prealbumin, undergoes glomerular filtration unhindered as a result of its low molecular weight; Human RBP is re-absorbed by the tubular cells and catabolized there.
NCBI and Uniprot Product Information
NCBI Description
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
Uniprot Description
RBP4: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency). This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. Belongs to the calycin superfamily. Lipocalin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component: extracellular space; protein complex; extracellular region; cytosol
Molecular Function: protein binding; protein heterodimerization activity; retinal binding; retinol binding
Biological Process: cardiac muscle development; phototransduction, visible light; retinal metabolic process; response to retinoic acid; urinary bladder development; heart development; embryonic skeletal development; maintenance of gastrointestinal epithelium; male gonad development; positive regulation of insulin secretion; vagina development; positive regulation of immunoglobulin secretion; glucose homeostasis; uterus development; response to insulin stimulus; gluconeogenesis; embryonic organ morphogenesis; response to ethanol; eye development; retinol metabolic process; negative regulation of cardiac muscle cell proliferation; embryonic retina morphogenesis in camera-type eye; detection of light stimulus involved in visual perception; spermatogenesis; retinoid metabolic process; female genitalia morphogenesis; lung development
Disease: Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome; Microphthalmia, Isolated, With Coloboma 10
Research Articles on RBP4
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Product Notes
The RBP4 rbp4 (Catalog #AAA173544) is a Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Retinol Binding Protein 4, Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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