Thyroid Peroxidase Recombinant Protein | r-hTPO recombinant protein
Recombinant Thyroid Peroxidase (r-TPO)
Applications
Western Blot
Purity
>= 96% (SDS-PAGE)
Synonyms
Thyroid Peroxidase; Recombinant Thyroid Peroxidase (r-TPO); Thyroid Peroxidase (TPO) - >=96% (SDS-PAGE); r-hTPO recombinant protein
Purity/Purification
>= 96% (SDS-PAGE)
Form/Format
Liquid
Sequence Length
38
Applicable Applications for r-hTPO recombinant protein
Western Blot (WB)
Application Notes
Application: Autoimmune capture in commercial assays
Source
Baculovirus, Sf9 Cells
Recertification
2 years
Protein
> 0.5 mg/mL
pH
7.6
Additional Info
Full-length protein, no tag sequences or membrane binding domain, and not enzymatically active
Preparation and Storage
At -20 degree C
Related Product Information for r-hTPO recombinant protein
Human Thyroid peroxidase (TPO) is an enzyme mainly expressed in the thyroid that liberates iodine for addition onto tyrosine residues on Thyroglobulin for the production of thyroxine (thyroid hormone).Thyroid Peroxidase is the antigenic determinant of the thyroid microsome associated with anti-TPO autoantibodies. Anti-TPO is an important secondary marker in the identification of Grave's and Hashimoto disease. Thyroid antibodies are also assiciated with infertility and fetal loss.
Technical support, bulk quantities and aliquoting available.
Technical support, bulk quantities and aliquoting available.
Product Categories/Family for r-hTPO recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
~104,000
NCBI Official Full Name
thyroid peroxidase, partial
Protein Family
NCBI Description
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
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Product Notes
The r-hTPO (Catalog #AAA172020) is a Recombinant Protein and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Thyroid Peroxidase can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Application: Autoimmune capture in commercial assays. Researchers should empirically determine the suitability of the r-hTPO for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Thyroid Peroxidase, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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