Rat Inactive caspase-12, CASP12 ELISA Kit | CASP12 elisa kit
Rat Inactive caspase-12, CASP12 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]
Uniprot Description
CASP12: Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. Belongs to the peptidase C14A family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.22.-
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component: cytoplasm
Molecular Function: cysteine-type endopeptidase activity
Biological Process: regulation of apoptosis; unfolded protein response; regulation of inflammatory response; proteolysis
Research Articles on CASP12
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Product Notes
The Rat CASP12 casp12 (Catalog #AAA1605005) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA1605005 ELISA Kit recognizes Rat CASP12. It is sometimes possible for the material contained within the vial of "Inactive caspase-12, CASP12, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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