KRT6A recombinant protein

Recombinant Human KRT6A protein

Cat. Num. AAA1562252

• Gene Names: KRT6A; K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; KRT6C; KRT6D
• Purity: >90% as determined by SDS-PAGE
• Synonyms: KRT6A; Recombinant Human KRT6A protein; Keratin; type II cytoskeletal 6A; Cytokeratin-6A; CK-6A; Cytokeratin-6D; CK-6D; Keratin-6A; K6A; Type-II keratin Kb6; Hom s 5; KRT6A recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human KRT6A (Glu163-Leu468) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for KRT6A recombinant protein

Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.

Product Categories/Family for KRT6A recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 1346344
• NCBI GeneID: 3853
• UniProt Accession #: P02538; P48667; Q08AR4; Q6NT67; Q96CL4; A4QPC1
• Molecular Weight: 564
• NCBI Official Full Name: Keratin, type II cytoskeletal 6A
• NCBI Official Synonym Full Names: keratin 6A
• NCBI Official Symbol: KRT6A
• NCBI Official Synonym Symbols: K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; KRT6C; KRT6D
• NCBI Protein Information: keratin, type II cytoskeletal 6A; KDAMP; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; type-II keratin Kb6; keratin, epidermal type II, K6A; kamp-keratin derived antimicrobial peptide
• UniProt Protein Name: Keratin, type II cytoskeletal 6A
• Protein Family: Keratin
• UniProt Gene Name: KRT6A
• UniProt Synonym Gene Names: K6A; KRT6D; CK-6A; CK-6D; K6A
• UniProt Entry Name: K2C6A_HUMAN

NCBI Description

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014]

Uniprot Description

K6a: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Associates with K16 and/or -17.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: membrane; keratin filament; nucleus

Molecular Function: protein binding; structural constituent of cytoskeleton

Biological Process: wound healing; positive regulation of cell proliferation; morphogenesis of an epithelium; cell differentiation

Disease: Pachyonychia Congenita 3