SOSTDC1 recombinant protein

Recombinant Human SOSTDC1 protein

Cat. Num. AAA1561827

• Gene Names: SOSTDC1; USAG1; CDA019; ECTODIN
• Purity: >90% as determined by SDS-PAGE
• Synonyms: SOSTDC1; Recombinant Human SOSTDC1 protein; Sclerostin domain-containing protein 1; Ectodermal BMP inhibitor; Ectodin; Uterine sensitization-associated gene 1 protein; USAG-1; SOSTDC1 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human SOSTDC1 (Phe24-Ser206) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for SOSTDC1 recombinant protein

May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.

Product Categories/Family for SOSTDC1 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 23943785
• NCBI GeneID: 25928
• NCBI Accession #: NP_056279.1
• NCBI GenBank Nucleotide #: NM_015464.2
• UniProt Accession #: Q6X4U4; Q96HJ7; Q9Y3U3; A8MUA6
• Molecular Weight: 26,260 Da
• NCBI Official Full Name: sclerostin domain-containing protein 1
• NCBI Official Synonym Full Names: sclerostin domain containing 1
• NCBI Official Symbol: SOSTDC1
• NCBI Official Synonym Symbols: USAG1; CDA019; ECTODIN
• NCBI Protein Information: sclerostin domain-containing protein 1; cystine-knot containing secreted protein; ectodermal BMP inhibitor; uterine sensitization-associated protein-1
• UniProt Protein Name: Sclerostin domain-containing protein 1
• Protein Family: Sclerostin domain-containing protein
• UniProt Gene Name: SOSTDC1
• UniProt Synonym Gene Names: USAG1; Ectodin; USAG-1
• UniProt Entry Name: SOSD1_HUMAN

NCBI Description

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]

Uniprot Description

SOSTDC1: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. Belongs to the sclerostin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7p21.1

Cellular Component: extracellular space

Biological Process: hair follicle morphogenesis; Wnt receptor signaling pathway; pattern specification process; odontogenesis of dentine-containing teeth; negative regulation of BMP signaling pathway; negative regulation of cell fate commitment