Lefty-A Recombinant Protein | LEFTY2 recombinant protein

Recombinant Human Lefty-A protein, N-His Tag

Cat. Num. AAA1560860

• Gene Names: LEFTY2; EBAF; LEFTA; TGFB4; LEFTYA
• Purity: >90% as determined by SDS-PAGE
• Synonyms: Lefty-A; Recombinant Human Lefty-A protein; N-His Tag; EBAF; LEFTA; LEFTYA; TGFB4; LEFTY2 recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Tag: N-His Tag
• Species: Homo sapiens (Human)
• Endotoxin Level: <1.0EU per ug of the protein as determined by the LAL method.
• Protein Construction: A DNA sequence encoding the human LEFTY2 (Phe78-Pro366) was fused with the N-terminal His Tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Product Categories/Family for LEFTY2 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 289063399
• NCBI GeneID: 7044
• NCBI Accession #: NP_001165896.1
• NCBI GenBank Nucleotide #: NM_001172425.1
• UniProt Accession #: O00292; O75611; Q5TE89; Q8NBQ9; B3KNH4; B4E332; E9PDM4
• Molecular Weight: 37,093 Da
• NCBI Official Full Name: left-right determination factor 2 isoform 2 preproprotein
• NCBI Official Synonym Full Names: left-right determination factor 2
• NCBI Official Symbol: LEFTY2
• NCBI Official Synonym Symbols: EBAF; LEFTA; TGFB4; LEFTYA
• NCBI Protein Information: left-right determination factor 2; TGF-beta-4; endometrial bleeding-associated factor; left-right determination factor A; protein lefty-2; protein lefty-A; transforming growth factor beta-4
• UniProt Protein Name: Left-right determination factor 2
• Protein Family: Left-right determination factor
• UniProt Gene Name: LEFTY2
• UniProt Synonym Gene Names: EBAF; LEFTA; LEFTYA; TGFB4; TGF-beta-4
• UniProt Entry Name: LFTY2_HUMAN

NCBI Description

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Uniprot Description

LEFTY2: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. Defects in LEFTY2 are the cause of left-right axis malformations (LRAM). The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava. Belongs to the TGF-beta family.

Protein type: Ligand, receptor tyrosine kinase; Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 1q42.1

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: regulation of apoptosis; platelet activation; platelet degranulation; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; multicellular organismal development; cell growth; blood coagulation; cell development