Western Blot (WB)
(Western blot analysis of MLXIP in MCF7 cell lysate with MLXIP antibody at 1 μg/mL.)
Rabbit MLXIP Polyclonal Antibody | anti-MLXIP antibody
MLXIP Antibody
Gene Names
MLXIP; MIR; MONDOA; bHLHe36
Reactivity
HumanPredicted: Mouse (95%)
Applications
ELISA, Western Blot
Purity
Affinity chromatography purified via peptide column.
Synonyms
MLXIP; Polyclonal Antibody; MLXIP Antibody; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; MLX interacting protein; anti-MLXIP antibody
Host
Rabbit
Reactivity
Human
Predicted: Mouse (95%)
Predicted: Mouse (95%)
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
919
Applicable Applications for anti-MLXIP antibody
ELISA (EIA), Western Blot (WB)
Application Notes
Western blot at 1 - 2 mug/mL.
Conjugate
Unconjugated
Immunogen
MLXIP antibody was raised against a peptide corresponding to 19 amino acids near the amino terminus of human MLXIP.
Buffer
MLXIP Antibody is supplied in PBS containing 0.02% sodium azide.
Species
Human
Preparation and Storage
Store at 4 degree C for three months and -20 degree C, stable for up to one year.
As with all antibodies care should be taken to avoid repeated freeze thaw cycles
Antibodies should not be exposed to prolonged high temperatures.
As with all antibodies care should be taken to avoid repeated freeze thaw cycles
Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of MLXIP in MCF7 cell lysate with MLXIP antibody at 1 μg/mL.)
Western Blot (WB)
(Western blot analysis of MLXIP in MCF7 cell lysate with MLXIP antibody at 1 μg/mL.)
Related Product Information for anti-MLXIP antibody
MLXIP Antibody: MLXIP is a member of the Myc superfamily of transcription factors and functions as part of a heterodimer with Max-like protein X (MLX) to activate transcription (1). MLXIP contributes to the regulation of glucose homeostasis as the MLXIP/MLX heterodimer activates expression of thioredoxin-interacting protein (TXNIP), a potent inhibitor of cellular glucose uptake and aerobic glycolysis. The mammalian target of rapamycin (mTOR) suppresses the activation of the TXNIP pathway by binding to MLXIP, thereby preventing the MLXIP/MLX heterodimer formation (2). MLXIP interaction with Myc may also be involved in metabolic reprogramming and tumorigenesis (3).
Product Categories/Family for anti-MLXIP antibody
References
1. Billin AN, Eilers AL, Coulter KL, et al. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. Mol. Cell Biol. 2000; 20:8845-54. 2. Kaadige MR, Yang J, Wilde BR, et al. MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction. Mol. Cell Biol. 2015; 35:101-10. 3. Carroll PA, Diolaiti D, McFerrin L, et al. Deregulated Myc requires ModoA/Mlx for metabolic reprogramming and tumorigenesis. Cancer Cell 2015; 27:271-85.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Predicted: 20 kDa
Observed: 21 kDa
Observed: 21 kDa
NCBI Official Full Name
MLX-interacting protein
NCBI Official Synonym Full Names
MLX interacting protein
NCBI Official Symbol
MLXIP
NCBI Official Synonym Symbols
MIR; MONDOA; bHLHe36
NCBI Protein Information
MLX-interacting protein
UniProt Protein Name
MLX-interacting protein
Protein Family
UniProt Gene Name
MLXIP
UniProt Synonym Gene Names
bHLHe36
NCBI Description
This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]
Uniprot Description
MLXIP: Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. 5 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: nucleus
Molecular Function: transcription factor activity
Research Articles on MLXIP
Similar Products
Product Notes
The MLXIP mlxip (Catalog #AAA154454) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MLXIP Antibody reacts with Human Predicted: Mouse (95%) and may cross-react with other species as described in the data sheet. AAA Biotech's MLXIP can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Western blot at 1 - 2 mug/mL. Researchers should empirically determine the suitability of the MLXIP mlxip for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MLXIP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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