APPBP2 blocking peptide

APPBP2 Peptide

Cat. Num. AAA153988

• Gene Names: APPBP2; PAT1; APP-BP2; HS.84084
• Applications: Blocking (BL)
• Synonyms: APPBP2; APPBP2 Peptide; PAT1; APP-BP2; HS.84084; KIAA0228; Amyloid protein-binding protein 2; Amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail) binding protein 2; APPBP2 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 585

• Applicable Applications for APPBP2 blocking peptide: Blocking (BL)
• Application Notes: The peptide is used for blocking the activity of APPBP2 antibody. It usually blocks the antibody activity completely by incubating the peptide with equal volume of antibody for 30 min at 37 degree C.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 18 amino acids near the carboxy terminus of human APPBP2.
• Preparation and Storage: Store APPBP2 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 18104962
• NCBI GeneID: 10513
• NCBI Accession #: NP_006371
• NCBI GenBank Nucleotide #: NM_006380.3
• UniProt Accession #: Q92624; O95095; Q8WVC9; A8K862
• Molecular Weight: 66,853 Da
• NCBI Official Full Name: amyloid protein-binding protein 2 isoform 1
• NCBI Official Synonym Full Names: amyloid beta precursor protein (cytoplasmic tail) binding protein 2
• NCBI Official Symbol: APPBP2
• NCBI Official Synonym Symbols: PAT1; APP-BP2; HS.84084
• NCBI Protein Information: amyloid protein-binding protein 2; protein interacting with APP tail 1
• UniProt Protein Name: Amyloid protein-binding protein 2
• Protein Family: Amyloid protein-binding protein
• UniProt Gene Name: APPBP2
• UniProt Synonym Gene Names: KIAA0228; PAT1; APP-BP2
• UniProt Entry Name: APBP2_HUMAN

NCBI Description

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

APPBP2: May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: microtubule; microtubule associated complex; cytoplasmic vesicle membrane; cytoplasm; nucleus

Molecular Function: protein binding; microtubule motor activity

Biological Process: intracellular protein transport; intracellular transport; metabolic process