ATG4C blocking peptide

ATG4C Peptide

Cat. Num. AAA153906

• Gene Names: ATG4C; APG4C; AUTL1; AUTL3; APG4-C
• Applications: Blocking (BL)
• Synonyms: ATG4C; ATG4C Peptide; APG4C; AUTL1; AUTL3; APG4-C; Cysteine protease ATG4C; AUT-like 3 cysteine endopeptidase; autophagy related 4C; cysteine peptidase; ATG4C blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 458

• Applicable Applications for ATG4C blocking peptide: Blocking (BL)
• Application Notes: The peptide is used for blocking the activity of ATG4C Antibody. It usually blocks the antibody activity completely by incubating the peptide with equal volume of antibody for 30 min at 37 degree C.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 18 amino acids near the carboxy terminus of human ATG4C.
• Preparation and Storage: Store ATG4C Peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 30410846
• NCBI GeneID: 84938
• NCBI Accession #: NP_835739
• NCBI GenBank Nucleotide #: NM_178221.2
• UniProt Accession #: Q96DT6; Q96K04; A6NLR8; D3DQ58
• Molecular Weight: 52,497 Da
• NCBI Official Full Name: cysteine protease ATG4C
• NCBI Official Synonym Full Names: autophagy related 4C, cysteine peptidase
• NCBI Official Symbol: ATG4C
• NCBI Official Synonym Symbols: APG4C; AUTL1; AUTL3; APG4-C
• NCBI Protein Information: cysteine protease ATG4C; autophagin-3; APG4 autophagy 4 homolog C; AUT-like 3 cysteine endopeptidase; ATG4 autophagy related 4 homolog C; AUT-like 1, cysteine endopeptidase; autophagy-related protein 4 homolog C; autophagy-related cysteine endopeptidase 3
• UniProt Protein Name: Cysteine protease ATG4C
• Protein Family: Cysteine protease
• UniProt Gene Name: ATG4C
• UniProt Synonym Gene Names: APG4C; AUTL1; AUTL3
• UniProt Entry Name: ATG4C_HUMAN

NCBI Description

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

ATG4C: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family.

Protein type: Autophagy; Protease; EC 3.4.22.-; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: cytoplasm; extracellular region; cytosol

Molecular Function: peptidase activity; cysteine-type endopeptidase activity

Biological Process: protein delipidation; mitochondrion degradation; autophagy; protein processing; C-terminal protein lipidation; protein targeting to membrane; proteolysis; autophagic vacuole formation; cellular response to nitrogen starvation