Rabbit BAFF Receptor Polyclonal Antibody | anti-TNFRSF13C antibody

BAFF Receptor Antibody

Cat. Num. AAA151185

• Gene Names: TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: BAFF Receptor Antibody is affinity chromatography purified via peptide column.
• Synonyms: BAFF Receptor; Polyclonal Antibody; BAFF Receptor Antibody; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin; BR3; Tumor necrosis factor receptor superfamily member 13C; B-cell-activating factor receptor; tumor necrosis factor receptor superfamily; member 13C; anti-TNFRSF13C antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: BAFF Receptor Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 184

• Applicable Applications for anti-TNFRSF13C antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: BAFF Receptor antibody can be used for detection of BAFF Rexeptor by Western blot at 5 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL.
• Conjugate: Unconjugated
• Immunogen: BAFF Receptor antibody was raised against a synthetic peptide corresponding to 15 amino acids near the carboxy terminus of human BAFF Receptor The peptide sequence is identical between human and mouse origin.
• Buffer: BAFF Receptor Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: BAFF Receptor antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of BAFF Receptor in human (H), mouse (M), and rat (R) spleen tissue lysates with BAFF Receptor antibody at 5 μg/mL. )

Immunohistochemistry (IHC)

(Immunohistochemistry of BAFF-R in human spleen tissue with BAFF-R antibody at 5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of BAFF-R in human spleen tissue with BAFF-R antibody at 20 μg/ml.Red: BAFF Receptor Antibody (3097)Blue: DAPI staining)

Immunohistochemistry (IHC)

(Immunohistochemistry of BAFF Receptor in human tonsil tissue with BAFF Receptor antibody at 5 μg/mL.)

Related Product Information for anti-TNFRSF13C antibody

BAFF Receptor Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-κB and c-jun N-terminal kinase.

NCBI and Uniprot Product Information

• NCBI GI #: 15208475
• NCBI GeneID: 115650
• UniProt Accession #: Q96RJ3
• Molecular Weight: 20 kDa
• NCBI Official Full Name: BAFF receptor
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 13C
• NCBI Official Symbol: TNFRSF13C
• NCBI Official Synonym Symbols: BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 13C; BAFF receptor; BLyS receptor 3; B cell-activating factor receptor; B-cell-activating factor receptor
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 13C
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF13C
• UniProt Synonym Gene Names: BAFFR; BR3; BAFF-R
• UniProt Entry Name: TR13C_HUMAN

NCBI Description

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

Uniprot Description

BAFF-R: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4); also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Receptor, misc.; Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 22q13.1-q13.31

Cellular Component: integral to membrane; external side of plasma membrane

Biological Process: B cell costimulation; B cell homeostasis; T cell costimulation; positive regulation of germinal center formation; positive regulation of B cell proliferation; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 4