Western Blot (WB)
(Western blot analysis of KPNA1 in Hela cell lysate with KPNA1 antibody at 1μg/mL.)
Rabbit KPNA1 Polyclonal Antibody | anti-KPNA1 antibody
KPNA1 Antibody
Western Blot (WB)
(Western blot analysis of KPNA1 in Hela cell lysate with KPNA1 antibody at 1μg/mL.)
Western Blot (WB)
(Western blot analysis of KPNA1 in Hela cell lysate with KPNA1 antibody at 1μg/mL.)
Immunocytochemistry (IHC)
(Immunocytochemistry of KPNA1 in HeLa cells with KPNA1 antibody at 2.5 μg/mL.)
Immunocytochemistry (IHC)
(Immunocytochemistry of KPNA1 in HeLa cells with KPNA1 antibody at 2.5 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of KPNA1 in K562 cells with KPNA1 antibody at 20 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of KPNA1 in K562 cells with KPNA1 antibody at 20 μg/mL.)
NCBI and Uniprot Product Information
NCBI Description
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Description
KPNA1: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Belongs to the importin alpha family.
Protein type: Adaptor/scaffold; Nuclear import; Karyopherin
Chromosomal Location of Human Ortholog: 3q21
Cellular Component: nucleoplasm; dendrite; cytoplasm; nuclear pore; cytosol; nucleus
Molecular Function: protein binding; nuclear localization sequence binding; protein transporter activity
Biological Process: viral reproduction; positive regulation of protein import into nucleus; apoptosis; regulation of DNA recombination; cytokine and chemokine mediated signaling pathway; NLS-bearing substrate import into nucleus; viral infectious cycle; DNA fragmentation during apoptosis; cell structure disassembly during apoptosis
Research Articles on KPNA1
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Product Notes
The KPNA1 kpna1 (Catalog #AAA151068) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KPNA1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's KPNA1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF). KPNA1 antibody can be used for detection of KPNA1 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the KPNA1 kpna1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KPNA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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