Western Blot (WB)
(Western blot analysis of SDHAF1 in 3T3 cell lysate with SDHAF1 antibody at (A) 1 and (B) 2 μg/mL.)
Rabbit anti-Human, Mouse SDHAF1 Polyclonal Antibody | anti-SDHAF1 antibody
SDHAF1 Antibody
Western Blot (WB)
(Western blot analysis of SDHAF1 in 3T3 cell lysate with SDHAF1 antibody at (A) 1 and (B) 2 μg/mL.)
Western Blot (WB)
(Western blot analysis of SDHAF1 in 3T3 cell lysate with SDHAF1 antibody at (A) 1 and (B) 2 μg/mL.)
Immunocytochemistry (IHC)
(Immunocytochemistry of SDHAF1 in 3T3 cells with SDHAF1 antibody at 5 μg/mL.)
Immunocytochemistry (IHC)
(Immunocytochemistry of SDHAF1 in 3T3 cells with SDHAF1 antibody at 5 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of SDHAF1 in 3T3 cells with SDHAF1 antibody at 20 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of SDHAF1 in 3T3 cells with SDHAF1 antibody at 20 μg/mL.)
NCBI and Uniprot Product Information
NCBI Description
The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency).[provided by RefSeq, Mar 2010]
Uniprot Description
SDHAF1: Plays an essential role in succinate dehydrogenase complex (SDH) assembly, a complex involved in complex II of the mitochondrial electron transport chain. Probably acts by participating in mitochondrial biosynthesis of iron-sulfur centers for complex II (Probable). Defects in SDHAF1 are a cause of mitochondrial complex II deficiency (MT-C2D); also known as SDH-defective infantile leukoencephalopathy. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations. Clinical features include psychomotor regression in infants, poor growth with lack of speech development, severe spastic quadriplegia, dystonia, progressive leukoencephalopathy, muscle weakness, exercise intolerance, cardiomyopathy. Some patients manifest Leigh syndrome or Kearns-Sayre syndrome. Belongs to the complex I LYR family. SDHAF1 subfamily.
Chromosomal Location of Human Ortholog: 19q13.12
Cellular Component: mitochondrion; mitochondrial matrix
Biological Process: iron-sulfur cluster assembly
Disease: Mitochondrial Complex Ii Deficiency
Research Articles on SDHAF1
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Product Notes
The SDHAF1 sdhaf1 (Catalog #AAA150667) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SDHAF1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SDHAF1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF). SDHAF1 antibody can be used for detection of SDHAF1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL. For immunofluorescence start at 5 mug/mL. Researchers should empirically determine the suitability of the SDHAF1 sdhaf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SDHAF1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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