Rabbit anti-Human, Mouse T-cadherin Polyclonal Antibody | anti-ENTPD3 antibody

T-cadherin Antibody

Cat. Num. AAA150632

• Gene Names: ENTPD3; HB6; CD39L3; NTPDase-3
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: T-cadherin Antibody is affinity chromatography purified via peptide column.
• Synonyms: T-cadherin; Polyclonal Antibody; T-cadherin Antibody; HB6; CD39L3; NTPDase-3; Ectonucleoside triphosphate diphosphohydrolase 3; CD39 antigen-like 3; NTPDase 3; ectonucleoside triphosphate diphosphohydrolase 3; anti-ENTPD3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least two isoforms of T-cadherin are known to exist.
• Purity/Purification: T-cadherin Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 2807

• Applicable Applications for anti-ENTPD3 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Application Notes: T-cadherin antibody can be used for the detection of T-cadherin by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: T-cadherin antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human T-cadherin.
• Buffer: T-cadherin Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: T-cadherin antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of T-cadherin in 3T3 lysate with T-cadherin antibody at (A) 0.5 and (B) 1 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of T-cadherin in K562 cells with T-cadherin antibody at 20 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of T-cadherin in 3T3 cells with T-cadherin antibody at 2 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of T cadherin in mouse brain tissue with T cadherin Antibody at 5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of T cadherin in mouse brain tissue with T cadherin Antibody at 20 μg/mL.Green: T-cadherin antibody (3583)Red: Phylloidin stainingBlue: DAPI staining)

Related Product Information for anti-ENTPD3 antibody

T-cadherin Antibody: T-cadherin was initially identified as cadherin-type cell adhesion molecule expressed in various neuronal populations in a temporally and spatially restricted pattern during axon growth. T-cadherin is an atypical member of the cadherin family because it does not possess the typical transmembrane and cytoplasmic domains but is instead anchored to the plasma membrane by glycosylphosphatidylinositol (GPI) linkage. T-cadherin may play a role in malignant tumor development as loss of the chromosome locus containing the T-cadherin gene correlates with the development of a variety of cancers. Recently it has been shown that T-cadherin can act as a receptor for hexameric and high-molecular weight forms of adiponectin, suggesting that T-cadherin may also play a role in metabolic regulation.

NCBI and Uniprot Product Information

• NCBI GI #: 166197701
• NCBI GeneID: 956
• NCBI Accession #: NP_001248
• NCBI GenBank Nucleotide #: NM_001248.2
• UniProt Accession #: O75355; O60495; Q8N6K2; B2R8D0; G5E9N0
• Molecular Weight: Predicted: 78; 84 kDa; ; Observed: 85 kDa
• NCBI Official Full Name: Homo sapiens ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3), mRNA
• NCBI Official Synonym Full Names: ectonucleoside triphosphate diphosphohydrolase 3
• NCBI Official Symbol: ENTPD3
• NCBI Official Synonym Symbols: HB6; CD39L3; NTPDase-3
• NCBI Protein Information: ectonucleoside triphosphate diphosphohydrolase 3; NTPDase 3; ecto-ATPase 3; ecto-ATPDase 3; ecto-apyrase 3; CD39 antigen-like 3; ecto-ATP diphosphohydrolase 3
• UniProt Protein Name: Ectonucleoside triphosphate diphosphohydrolase 3
• Protein Family: Ectonucleoside triphosphate diphosphohydrolase
• UniProt Gene Name: ENTPD3
• UniProt Synonym Gene Names: CD39L3; NTPDase 3; Ecto-ATPDase 3; Ecto-ATPase 3
• UniProt Entry Name: ENTP3_HUMAN

NCBI Description

This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]

Uniprot Description

ENTPD3: Has a threefold preference for the hydrolysis of ATP over ADP. Belongs to the GDA1/CD39 NTPase family.

Protein type: Membrane protein, integral; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Phosphatase (non-protein); Membrane protein, multi-pass; EC 3.6.1.5; Hydrolase

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: nucleoside-diphosphatase activity; nucleoside-triphosphatase activity; ATP binding

Biological Process: nucleoside diphosphate catabolic process; nucleoside triphosphate catabolic process