Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human liver cancer using MBS1493438 at dilution 1:100)
Rabbit anti-Human Deoxyguanosine kinase Polyclonal Antibody | anti-DGK antibody
Rabbit anti-human Deoxyguanosine kinase, mitochondrial polyclonal Antibody
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human liver cancer using MBS1493438 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human liver cancer using MBS1493438 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS1493438 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS1493438 at dilution 1:100)
NCBI and Uniprot Product Information
NCBI Description
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
DGUOK: Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Defects in DGUOK are the cause of mitochondrial DNA depletion syndrome type 3 (MTDPS3). A disorder characterized by onset in infancy of progressive liver failure, hypoglycemia, increased lactate in body fluids, and neurologic abnormalities including hypotonia, encephalopathy, peripheral neuropathy. Affected tissues show both decreased activity of the mtDNA-encoded respiratory chain complexes and mtDNA depletion. Belongs to the DCK/DGK family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleotide Metabolism - purine; Kinase, other; EC 2.7.1.113; Mitochondrial
Chromosomal Location of Human Ortholog: 2p13
Cellular Component: cytosol; mitochondrial matrix; mitochondrion; nucleus
Molecular Function: ATP binding; deoxyguanosine kinase activity; nucleoside kinase activity
Biological Process: deoxyribonucleoside monophosphate biosynthetic process; dGTP metabolic process; guanosine metabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleotide biosynthetic process; protein amino acid phosphorylation; purine base metabolic process; purine deoxyribonucleoside metabolic process; purine salvage
Disease: Mitochondrial Dna Depletion Syndrome 3 (hepatocerebral Type)
Research Articles on DGK
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Product Notes
The DGK dguok (Catalog #AAA1493438) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Deoxyguanosine kinase, mitochondrial polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Deoxyguanosine kinase can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the DGK dguok for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Deoxyguanosine kinase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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