Rabbit anti-Human TBX15 Polyclonal Antibody | anti-TBX15 antibody

TBX15 Antibody

Cat. Num. AAA1492639

• Gene Names: TBX15; TBX14
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >95%, Protein G Purified
• Synonyms: TBX15; Polyclonal Antibody; TBX15 Antibody; T-box transcription factor TBX15; T-box protein 15; TBX14; T-box transcription factor TBX14; T-box protein 14; anti-TBX15 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G Purified
• Sequence Length: 496

• Applicable Applications for anti-TBX15 antibody: ELISA (EIA), Western Blot (WB)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Non-conjugated
• Immunogen: Recombinant human T-box transcription factor TBX15 protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-17893 / sc-134059 / sc-134059
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: TBX15 antibody at 5ug/ml+ Hela whole cell lysateGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 66,55 kDaObserved band size: 66 kDa)

Related Product Information for anti-TBX15 antibody

Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 55770860
• NCBI GeneID: 6913
• NCBI Accession #: NP_689593.2
• NCBI GenBank Nucleotide #: NM_152380.2
• UniProt Accession #: Q96SF7; Q08E76; Q5JT54; Q5T9S7
• Molecular Weight: 54,671 Da
• NCBI Official Full Name: T-box transcription factor TBX15
• NCBI Official Synonym Full Names: T-box 15
• NCBI Official Symbol: TBX15
• NCBI Official Synonym Symbols: TBX14
• NCBI Protein Information: T-box transcription factor TBX15
• UniProt Protein Name: T-box transcription factor TBX15
• Protein Family: T-box transcription factor
• UniProt Gene Name: TBX15
• UniProt Synonym Gene Names: TBX14; T-box protein 15; T-box protein 14
• UniProt Entry Name: TBX15_HUMAN

NCBI Description

This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome.[provided by RefSeq, Oct 2009]

Uniprot Description

TBX15: Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes. Defects in TBX15 are the cause of Cousin syndrome (COUSS); also known as craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature. Cousin syndrome is defined as pelviscapular dysplasia with epiphyseal abnormalities, congenital dwarfism and facial dysmorphy (frontal bossing, hypertelorism, narrow palpebral fissures, deep set globes, strabismus, low-set posteriory rotated and unusually formed external ears, dysplasia of conchae, small chin, short neck with redundant skin folds, and a low hairline). Intelligence may vary from normal to moderately impaired. Radiographic features comprise aplasia of the body of the scapula, hypoplasia of the iliac bone, humeroradial synosthosis, dislocation of the femoral heads, and moderate brachydactyly. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 1p11.1

Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: embryonic cranial skeleton morphogenesis; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent

Disease: Cousin Syndrome