Rabbit anti-Human Phospholipid transfer Polyclonal Antibody | anti-PLTP antibody

Rabbit anti-human Phospholipid transfer polyclonal Antibody, Biotin conjugated

Cat. Num. AAA1488916

• Gene Names: PLTP; BPIFE; HDLCQ9
• Reactivity: Human
• Applications: ELISA
• Purity: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Synonyms: Phospholipid transfer; Polyclonal Antibody; Rabbit anti-human Phospholipid transfer polyclonal Antibody; Biotin conjugated; Lipid transfer protein II PLTP; anti-PLTP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Sequence Length: 398

• Applicable Applications for anti-PLTP antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Biotin
• Immunogen: Recombinant human Phospholipid transfer protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-30835 / sc-32901
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreas at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney at dilution 1:100)

Related Product Information for anti-PLTP antibody

Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.

NCBI and Uniprot Product Information

• NCBI GI #: 339275807
• NCBI GeneID: 5360
• NCBI Accession #: NP_001229849.1
• NCBI GenBank Nucleotide #: NM_001242920.1
• UniProt Accession #: P55058; Q8WTT1; Q9BR07; Q9BSH8; A8K006; B4DDD5; B4DRB4; E1P5N8; E7EV16
• Molecular Weight: 44,847 Da
• NCBI Official Full Name: phospholipid transfer protein isoform c
• NCBI Official Synonym Full Names: phospholipid transfer protein
• NCBI Official Symbol: PLTP
• NCBI Official Synonym Symbols: BPIFE; HDLCQ9
• NCBI Protein Information: phospholipid transfer protein
• UniProt Protein Name: Phospholipid transfer protein
• Protein Family: Phospholipid transfer protein
• UniProt Gene Name: PLTP
• UniProt Entry Name: PLTP_HUMAN

NCBI Description

The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

PLTP: Converts HDL into larger and smaller particles. May play a key role in extracellular phospholipid transport and modulation of hdl particles. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Lipid-binding

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: extracellular region; extracellular space

Molecular Function: lipid binding

Biological Process: lipid metabolic process; lipid transport; sperm motility; vitamin E biosynthetic process