Complement C6 Protein | C6 protein

Human Complement C6

Cat. Num. AAA147389

• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Complement C6; Human Complement C6; Complement C6 Human; Complement component C6; C6; C6 Human; C6 protein

• Host: Human Plasma
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: C6 protein solution contains phosphate buffer saline, pH7.2.; Sterile filtered solution.

• Human Virus Test: Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV and HBSAG.
• Preparation and Storage: C6 Human is stable at 4 degree C if entire vial will be used within 2-4 weeks.; Store, frozen below -20 degree C for longer periods of time.; For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).; Avoid multiple freeze-thaw cycles.

Related Product Information for C6 protein

Introduction: C6 is necessary for membrane attack complex formation and is activated by binding to recently-formed C5b at the cell membrane.Each pathway of complement activation generates proteolytic enzyme complexes which are bound to the target surface. These enzymes cleave a peptide bond in the larger alpha chain of C5 releasing C5a and activating C5b. Although C5b is unstable it remains bound to the activating complex for a few minutes during which it binds a single C6 from the surrounding fluid or it decays and is no longer capable of forming MAC. The C5b,6 complex may also remain connected to the C3/C5 convertase where the binding of a single C7 exposes a membrane-binding region and C5b,6,7 can enter into the bilipid layer of the target cell.
Description: Human Complement C6 produced in Human plasma having a molecular mass of 105kDa.

Product Categories/Family for C6 protein

RECOMBINANT & NATURAL PROTEINS

NCBI and Uniprot Product Information

• NCBI GI #: 169636415
• NCBI GeneID: 729
• NCBI Accession #: NP_000056.2
• NCBI GenBank Nucleotide #: NM_000065.3
• UniProt Accession #: P13671
• Molecular Weight: 105 KD
• NCBI Official Full Name: complement component C6
• NCBI Official Synonym Full Names: complement component 6
• NCBI Official Symbol: C6
• NCBI Protein Information: complement component C6
• UniProt Protein Name: Complement component C6
• Protein Family: Complement component
• UniProt Gene Name: C6
• UniProt Entry Name: CO6_HUMAN

NCBI Description

This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]

Uniprot Description

C6: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C6 are the cause of complement component 6 deficiency (C6D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: membrane attack complex; extracellular region

Molecular Function: protein binding

Biological Process: positive regulation of angiogenesis; positive regulation of activation of membrane attack complex; in utero embryonic development; cytolysis; regulation of complement activation; innate immune response; complement activation, classical pathway; complement activation

Disease: Complement Component 6 Deficiency