Mouse anti-Human 2, 3-Bisphosphoglycerate Mutase Monoclonal Antibody | anti-BPGM antibody
Mouse Anti Human 2, 3-Bisphosphoglycerate Mutase
Gene Names
BPGM; DPGM
Reactivity
Human
Applications
ELISA, Western Blot, Flow Cytometry, Functional Assay, Immunocytochemistry, Immunofluorescence
Purity
Purified from mouse ascitic fluids by protein-A affinity chromatography
Synonyms
2; 3-Bisphosphoglycerate Mutase; Monoclonal Antibody; Mouse Anti Human 2; Bisphosphoglycerate mutase; EC 5.4.2.4; BPGM; 3-bisphosphoglycerate mutase erythrocyte; 3-bisphosphoglycerate synthase; BPG-dependent PGAM; BPGM Antibody; Mouse Anti Human; anti-BPGM antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2a heavy chain and K light chain
Clone Number
PA2E11AT
Purity/Purification
Purified from mouse ascitic fluids by protein-A affinity chromatography
Form/Format
Sterile filtered colorless solution
1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide
1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide
Sequence Length
259
Applicable Applications for anti-BPGM antibody
ELISA (EIA), Western Blot (WB), Flow cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
Immunogen
Anti-human BPGM mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human BPGM amino acids 1-259 purified from E Coli
Preparation and Storage
For periods up to 1 month store at 4 degree C, for longer periods of time, store at-20 degree C.
Prevent freeze thaw cycles
Prevent freeze thaw cycles
Related Product Information for anti-BPGM antibody
BPGM is found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. PGM deficiency increases the oxygen affinity of cells. BPGM is a multifunctional enzyme that catalyzes 2, 3-DPG synthesis through its synthetase activity, and 2, 3-DPG degradation using its phosphatase activity. BPGM has phosphoglycerate phosphomutase activity. Mutations in BPGM cause hemolytic anemia. BPGM catalyzes the reaction of EC 5.4.2.1 (mutase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
Product Categories/Family for anti-BPGM antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
30,005 Da
NCBI Official Full Name
Bisphosphoglycerate mutase
NCBI Official Synonym Full Names
bisphosphoglycerate mutase
NCBI Official Symbol
BPGM
NCBI Official Synonym Symbols
DPGM
NCBI Protein Information
bisphosphoglycerate mutase
UniProt Protein Name
Bisphosphoglycerate mutase
Protein Family
UniProt Gene Name
BPGM
UniProt Synonym Gene Names
DPGM
NCBI Description
2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]
Uniprot Description
Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) activity.
Research Articles on BPGM
Similar Products
Product Notes
The BPGM bpgm (Catalog #AAA146980) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti Human 2, 3-Bisphosphoglycerate Mutase reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's 2, 3-Bisphosphoglycerate Mutase can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Flow cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF). Researchers should empirically determine the suitability of the BPGM bpgm for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "2, 3-Bisphosphoglycerate Mutase, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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