Mouse anti-Human Cyclin-Dependent Kinase Inhibitor 1B Monoclonal Antibody | anti-CDKN1B antibody

Mouse Anti Human Cyclin-Dependent Kinase Inhibitor 1B

Cat. Num. AAA146675

• Gene Names: CDKN1B; KIP1; MEN4; CDKN4; MEN1B; P27KIP1
• Reactivity: Human
• Applications: ELISA, Western Blot, Flow Cytometry, Functional Assay, Immunocytochemistry, Immunofluorescence
• Purity: Antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
• Synonyms: Cyclin-Dependent Kinase Inhibitor 1B; Monoclonal Antibody; Mouse Anti Human Cyclin-Dependent Kinase Inhibitor 1B; CDKN1B Antibody; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1; CDKN1B; KIP1; MEN4; CDKN4; MEN1B; Mouse Anti Human; anti-CDKN1B antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1 heavy chain and k light chain.
• Clone Number: PAT7B9AT
• Purity/Purification: Antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
• Form/Format: Sterile filtered colorless solution.; 1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.
• Sequence Length: 198

• Applicable Applications for anti-CDKN1B antibody: ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
• Immunogen: Anti-human CDKN1B mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CDKN1B amino acids 1-198 purified from E Coli.
• Preparation and Storage: 12 months at -20 degree C. 1 month at 4 degree C.; For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.

Related Product Information for anti-CDKN1B antibody

Cyclin-dependent kinase inhibitor 1B (CDKN1B) is a member of the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The CDKN1B protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and so controls the cell cycle progression at G1. CDKN1B is often referred to as a cell cycle inhibitor protein since its major function is to stop or slow down the cell division cycle. The degradation of the CDKN1B protein, which is triggered by its CDK dependent phosphorylation and ensuing ubiquitination by SCF complexes, is compulsory for the cellular transition from inactive to the proliferative state.

Product Categories/Family for anti-CDKN1B antibody

Monoclonal Antibodies; Anti-Human Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 4757962
• NCBI GeneID: 1027
• NCBI Accession #: NP_004055.1
• NCBI GenBank Nucleotide #: NM_004064.4
• UniProt Accession #: P46527; Q16307; Q5U0H2; Q9BUS6
• Molecular Weight: 22,073 Da
• NCBI Official Full Name: cyclin-dependent kinase inhibitor 1B
• NCBI Official Synonym Full Names: cyclin dependent kinase inhibitor 1B
• NCBI Official Symbol: CDKN1B
• NCBI Official Synonym Symbols: KIP1; MEN4; CDKN4; MEN1B; P27KIP1
• NCBI Protein Information: cyclin-dependent kinase inhibitor 1B
• UniProt Protein Name: Cyclin-dependent kinase inhibitor 1B
• Protein Family: Cyclin-dependent kinase inhibitor
• UniProt Gene Name: CDKN1B
• UniProt Synonym Gene Names: KIP1

NCBI Description

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

Uniprot Description

p27Kip1: a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. May mediate TGF beta-induced g1 arrest. Its degradation is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

Protein type: Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 12p13.1

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: caspase activator activity; cyclin-dependent protein kinase inhibitor activity; protein binding; protein phosphatase binding; transforming growth factor beta receptor, cytoplasmic mediator activity

Biological Process: autophagic cell death; caspase activation; cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of kinase activity; negative regulation of mitotic cell cycle; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; positive regulation of cell cycle; positive regulation of protein catabolic process; regulation of cyclin-dependent protein kinase activity

Disease: Multiple Endocrine Neoplasia, Type Iv