Golgi to ER traffic protein 4 homolog (Get4) Recombinant Protein | Get4 recombinant protein

Recombinant Mouse Golgi to ER traffic protein 4 homolog (Get4)

Cat. Num. AAA1463333

• Gene Names: Get4; Cee; AW412535; 1110007L15Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Golgi to ER traffic protein 4 homolog (Get4); Recombinant Mouse Golgi to ER traffic protein 4 homolog (Get4); Get4 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-327, full length protein
• Sequence: AAAAAMAEQEGARNGARNRGGVQRVEGKLRASVEKGDYYEAHQMYRTLFFRYMSQSKHAEARELMYSGALLFFSHGQQNSAADLSMLVLESLEKAEVDVADELLENLAKVFSLMDPNSPERVAFVSRALKWSSGGSGKLGHPRLHQLLALTLWKEQNYCESRYHFLHSSDGEGCANMLVEYSTARGFRSEVDMFVAQAVLQFLCLKNKNSALVVFTTYTQKHPSIEDGPPFVQPLLNFIWFLLLAVDGGKLAVFTVLCEQYQPSLRRDPMYNEYLDRIGQLFFGVPPKQTSSYGGLLGNLLSSLMGSSEQEEGEESQDDSSPIELD
• Sequence Length: 326

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 254281178
• NCBI GeneID: 67604
• NCBI Accession #: NP_001156788.1
• NCBI GenBank Nucleotide #: NM_001163316.1
• UniProt Accession #: Q9D1H7; Q78J86
• Molecular Weight: 30,560 Da
• NCBI Official Full Name: Golgi to ER traffic protein 4 homolog isoform 2
• NCBI Official Synonym Full Names: golgi to ER traffic protein 4
• NCBI Official Symbol: Get4
• NCBI Official Synonym Symbols: Cee; AW412535; 1110007L15Rik
• NCBI Protein Information: Golgi to ER traffic protein 4 homolog
• UniProt Protein Name: Golgi to ER traffic protein 4 homolog
• Protein Family: Golgi to ER traffic protein
• UniProt Gene Name: Get4

Uniprot Description

As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.