Interleukin-22 Active Protein | mIL 22A active protein
Recombinant Mouse Interleukin-22 Antagonist (E117A)
Gene Names
Il22; IL-22; Iltif; IL-22a; ILTIFa
Purity
Greater than 98.0% as determined by: (a) Gel filtration chromatography under non-denaturing conditions. (b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
Synonyms
Interleukin-22; Recombinant Mouse Interleukin-22 Antagonist (E117A); IL-22 Antagonist Mouse; Interleukin-22 Antagonist (E117A) Mouse Recombinant; IL-TIF; TIFa; IL-10-related T-cell-derived-inducible factor; IL-22; ILTIF; IL-D110; zcyto18; MGC79382; MGC79384; TIFIL-23; mIL 22A active protein
Host
E Coli
Purity/Purification
Greater than 98.0% as determined by: (a) Gel filtration chromatography under non-denaturing conditions. (b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
Form/Format
IL-22 Antagonist Mouse is lyophilized from a concentrated (1mg/ml) solution in water containing NaHCO3.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence
The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Leu-Pro-Val-Asn
Sequence Length
179
Solubility
It is recommended to reconstitute the lyophilized Interleukin -22 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
IL-22 E117A mutant is capable of full inhibition of STAT3 phosphorylation induced by mouse interleukin 22 in HepG cells. Its affinity toward immobilized mIL-22 receptor a1 extracellular domain (mIL-22 Ra1-ECD) or IL-22 binding protein is similar to the non-mutated mouse interleukin 22. Mouse IL-22 antagonist (E117A) has very low agonistic activity in this bioassay.
Preparation and Storage
Lyophilized Interleukin-22 Mouse Antagonist although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL22 Antagonist should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.
Related Product Information for mIL 22A active protein
Description: Interleukin-22 Antagonist Mouse Recombinant produced in E Coli is a single, non-glycosylated homodimeric polypeptide chain containing 147 amino acids and having a total molecular mass of 16.7 KDa. The Mouse IL-22 Antagonist is purified by proprietary chromatographic techniques.
Introduction: IL-22 is a member of the IL-10 family of regulatory cytokines.Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-beta/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.
Introduction: IL-22 is a member of the IL-10 family of regulatory cytokines.Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-beta/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.
Product Categories/Family for mIL 22A active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
20,106 Da
NCBI Official Full Name
interleukin-22
NCBI Official Synonym Full Names
interleukin 22
NCBI Official Symbol
Il22
NCBI Official Synonym Symbols
IL-22; Iltif; IL-22a; ILTIFa
NCBI Protein Information
interleukin-22; IL-10-related T-cell-derived-inducible factor; IL-TIF alpha; ILTIF alpha; interleukin 10-related T cell-derived inducible factor; interleukin-22a
UniProt Protein Name
Interleukin-22
Protein Family
UniProt Gene Name
Il22
UniProt Synonym Gene Names
Il22a; Iltif; Iltifa; IL-22; IL-TIF; IL-22a
UniProt Entry Name
IL22_MOUSE
Uniprot Description
IL22: Cytokine that contributes to the inflammatory response in vivo. Belongs to the IL-10 family.
Protein type: Secreted, signal peptide; Cytokine; Secreted
Cellular Component: extracellular space; extracellular region
Molecular Function: protein binding; cytokine activity
Biological Process: negative regulation of inflammatory response; regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of transcription from RNA polymerase II promoter
Research Articles on mIL 22A
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Product Notes
The mIL 22A il22 (Catalog #AAA145075) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Leu-Pr o-Val-Asn. It is sometimes possible for the material contained within the vial of "Interleukin-22, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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