Interleukin-36 Active Protein | mIL36A active protein
Recombinant Mouse Interleukin-36 Alpha 153 a.a.
Gene Names
Il1f6; Fil1; Il1f9; Il36a; IL-1H1; IL1RP2
Purity
Greater than 95.0% as determined by SDS-PAGE and HPLC analyses.
Synonyms
Interleukin-36; Recombinant Mouse Interleukin-36 Alpha 153 a.a.; IL36A 153 a.a. Mouse; Interleukin-36 Alpha 153 a.a Mouse Recombinant; Interleukin 36 alpha; FIL1E; IL1F6; FIL1; IL1(EPSILON); interleukin 1 family member 6 (epsilon); MGC129552; MGC129553; mIL36A 153 a.a.; mIL36A active protein
Host
E Coli
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE and HPLC analyses.
Form/Format
Lyophilized from a 0.2?m filtered concentrated solution in 1xPBS, pH 7.4 and 5% trehalose.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence
RAASPSLRHV QDLSSRVWIL QNNILTAVPR KEQTVPVTIT LLPCQYLDTL ETNRGDPTYM GVQRPMSCLF CTKDGEQPVL QLGEGNIMEM YNKKEPVKAS LFYHKKSGTT STFESAAFPG WFIAVCSKGS CPLILTQELG EIFITDFEMI VVH
Sequence Length
160
Solubility
It is recommended to reconstitute the lyophilized IL36A 153 a.a. Mouse in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
Fully biologically active when compared to standard. The ED50 as measured by its ability to induce IL-6 secretion in NIH-3T3 mouse embryonic fibroblast cells is less than 20ng/ml, corresponding to a specific activity of 50,000IU/mg.
Related Product Information for mIL36A active protein
Description: IL36A 153 a.a. Mouse Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 153 amino acids (8-160a.a.) and having a molecular mass of 17.0kDa.The IL36A 153 a.a. Mouse is purified by proprietary chromatographic techniques.
Introduction: Murine IL-36a belongs to the IL-1 family that includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL1F5), IL-36b (IL1F8), IL-36g (IL1F9), IL-37 (IL1F7) and IL-38 (IL-1F10). The IL-1 family members display a 12 b-strand, b-trefoil configuration, and are thought to have ascended from a mutual ancestral gene. Murine IL-36a is a 160 amino acid intracellular and secreted protein which holds no signal sequence, no prosegment and no potential N-linked glycosylation sites. IL-36a is released as a reaction to LPS and the cell ATP-induced activation of the P2X7 receptor. Mouse to human, full length IL-36a/IL-1F6 shares 54% aa sequence homology. IL-36a is mostly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine.
Introduction: Murine IL-36a belongs to the IL-1 family that includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL1F5), IL-36b (IL1F8), IL-36g (IL1F9), IL-37 (IL1F7) and IL-38 (IL-1F10). The IL-1 family members display a 12 b-strand, b-trefoil configuration, and are thought to have ascended from a mutual ancestral gene. Murine IL-36a is a 160 amino acid intracellular and secreted protein which holds no signal sequence, no prosegment and no potential N-linked glycosylation sites. IL-36a is released as a reaction to LPS and the cell ATP-induced activation of the P2X7 receptor. Mouse to human, full length IL-36a/IL-1F6 shares 54% aa sequence homology. IL-36a is mostly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine.
Product Categories/Family for mIL36A active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
18,015 Da
NCBI Official Full Name
interleukin-36 alpha
NCBI Official Synonym Full Names
interleukin 1 family, member 6
NCBI Official Symbol
Il1f6
NCBI Official Synonym Symbols
Fil1; Il1f9; Il36a; IL-1H1; IL1RP2
NCBI Protein Information
interleukin-36 alpha; FIL1 epsilon; Fil1epsilon; IL-1 epsilon; IL-1F6; interleukin 1 family, member 6 (epsilon); interleukin 1 family, member 9; interleukin-1 epsilon; interleukin-1 family member 6; interleukin-1 homolog 1
UniProt Protein Name
Interleukin-36 alpha
Protein Family
UniProt Gene Name
Il36a
UniProt Synonym Gene Names
Fil1e; Il1e; Il1f6; Il1h1; IL-1 epsilon; IL-1F6; IL-1H1
UniProt Entry Name
IL36A_MOUSE
Uniprot Description
IL1F6: Belongs to the IL-1 family.
Protein type: Cytokine
Cellular Component: extracellular space; extracellular region
Molecular Function: interleukin-1 receptor binding; cytokine activity
Biological Process: positive regulation of cytokine production; immune system process; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-6 production; innate immune response; immune response; inflammatory response
Research Articles on mIL36A
Similar Products
Product Notes
The mIL36A il36a (Catalog #AAA144849) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: RAASPSLRHV QDLSSRVWIL QNNILTAVPR KEQTVPVTIT LLPCQYLDTL ETNRGDPTYM GVQRPMSCLF CTKDGEQPVL QLGEGNIMEM YNKKEPVKAS LFYHKKSGTT STFESAAFPG WFIAVCSKGS CPLILTQELG EIFITDFEMI VVH. It is sometimes possible for the material contained within the vial of "Interleukin-36, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
