POU class 2 associating factor 1 Recombinant Protein | POU2AF1 recombinant protein

Recombinant Human POU class 2 associating factor 1

Cat. Num. AAA144752

• Gene Names: POU2AF1; BOB1; OBF1; OCAB; OBF-1
• Purity: Greater than 85.0% as determined by SDS-PAGE.
• Synonyms: POU class 2 associating factor 1; Recombinant Human POU class 2 associating factor 1; POU2AF1 Human; POU class 2 associating factor 1 Human Recombinant; POU domain class 2 associating factor 1; BOB-1; OCA-B; B-cell-specific coactivator OBF-1; OCT-binding factor 1; POU2AF1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 85.0% as determined by SDS-PAGE.
• Form/Format: POU2AF1 protein (0.5mg/ml) is supplied in 20mM Tris-HCL, pH-8 and 20% Glycerol.; POU2AF1 is supplied as a sterile filtered clear solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MLWQKPTAPE QAPAPARPYQ GVRVKEPVKE LLRRKRGHAS SGAAPAPTAV VLPHQPLATY TTVGPSCLDM EGSVSAVTEE AALCAGWLSQ PTPATLQPLA PWTPYTEYVP HEAVSCPYSA DMYVQPVCPS YTVVGPSSVL TYASPPLITN VTTRSSATPA VGPPLEGPEH QAPLTYFPWP QPLSTLPTST LQYQPPAPAL PGPQFVQLPI SIPEPVLQDM EDPRRAASSL TIDKLLLEEE DSDAYALNHT LSVEGF
• Sequence Length: 256

Related Product Information for POU2AF1 recombinant protein

Description: POU2AF1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 276 amino acids (1-256) and having a molecular mass of 29.6 kDa.The POU2AF1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: POU2AF1 is a lymphocyte specific transcription coactivator protein. POU2AF1 cooperates only with the Oct1/2 proteins using sub domains in the POU domain of the Oct1/2 proteins, increasing their transcriptional efficiency. Even though POU2AF1 have no basic ability to bind DNA, it links firmly with the octomer motif in the presence of Oct1 and Oct2. POU2AF1 is expressed at maximum levels in spleen and peripheral blood leukocytes.

Product Categories/Family for POU2AF1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; POU Class

NCBI and Uniprot Product Information

• NCBI GI #: 167900478
• NCBI GeneID: 5450
• NCBI Accession #: NP_006226.2
• NCBI GenBank Nucleotide #: NM_006235.2
• UniProt Accession #: Q16633; Q14983; B2R8Z9; AAB34937
• Molecular Weight: 27,436 Da
• NCBI Official Full Name: POU domain class 2-associating factor 1
• NCBI Official Synonym Full Names: POU class 2 associating factor 1
• NCBI Official Symbol: POU2AF1
• NCBI Official Synonym Symbols: BOB1; OBF1; OCAB; OBF-1
• NCBI Protein Information: POU domain class 2-associating factor 1; B-cell-specific coactivator OBF-1; BOB-1; OCA-B; OCT-binding factor 1; POU domain, class 2, associating factor 1
• UniProt Protein Name: POU domain class 2-associating factor 1
• Protein Family: POU domain class 2-associating factor
• UniProt Gene Name: POU2AF1
• UniProt Synonym Gene Names: OBF1
• UniProt Entry Name: OBF1_HUMAN

Uniprot Description

POU2AF1: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6. Belongs to the POU2AF1 family.

Protein type: Transcription, coactivator/corepressor; Oncoprotein

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: nucleus

Molecular Function: protein binding; DNA binding; transcription coactivator activity; transcription cofactor activity

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; humoral immune response