BCL2 Like 2 Recombinant Protein | BCL2L2 recombinant protein

Recombinant Human BCL2 Like 2, His Tag

Cat. Num. AAA143926

• Gene Names: BCL2L2; BCLW; BCL-W; PPP1R51; BCL2-L-2
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: BCL2 Like 2; Recombinant Human BCL2 Like 2; His Tag; BCL2L2 Human; His; BCL2 Like 2 Human Recombinant; B-Cell Lymphoma Protein 2; BCL2 Like protein 2; BCLW; Bcl2-L-2; Apoptosis regulator Bcl-W; BCL2L2; BCL-W; KIAA0271; BCL2L2 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: The BCL2L2 protein solution contains 20mM Tris-HCl, pH-8, 100mM NaCl and 10% glycerol.; Sterile filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETRLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RT
• Sequence Length: 193

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Related Product Information for BCL2L2 recombinant protein

Description: BCL2L2 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (1-172 a.a.) and having a molecular weight of 20.9kDa.The BCL2L2 is fused to a 20 a.a His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. BCL2L2 is part of the BCL-2 protein family which form hetero- or homodimers and play an important role as anti and proapoptotic regulators. BCL2L2 causes reduced cell apoptosis under cytotoxic conditions. BCL2L2 is involved in the survival of NGF- and BDNF-dependent neurons. BCL2L2 plays an important role in adult spermatogenesis.

Product Categories/Family for BCL2L2 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; B Cell Lymphoma

NCBI and Uniprot Product Information

• NCBI GI #: 315360668
• NCBI GeneID: 599
• NCBI Accession #: NP_001186768.1
• NCBI GenBank Nucleotide #: NM_001199839.1
• UniProt Accession #: Q92843; Q2M3U0; Q5U0H4; A8K0F4
• Molecular Weight: 37,171 Da
• NCBI Official Full Name: bcl-2-like protein 2
• NCBI Official Synonym Full Names: BCL2-like 2
• NCBI Official Symbol: BCL2L2
• NCBI Official Synonym Symbols: BCLW; BCL-W; PPP1R51; BCL2-L-2
• NCBI Protein Information: bcl-2-like protein 2; apoptosis regulator BCL-W; protein phosphatase 1, regulatory subunit 51
• UniProt Protein Name: Bcl-2-like protein 2
• Protein Family: Bcl-2-like protein
• UniProt Gene Name: BCL2L2
• UniProt Synonym Gene Names: BCLW; KIAA0271; Bcl2-L-2
• UniProt Entry Name: B2CL2_HUMAN

NCBI Description

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

Uniprot Description

BCL2L2: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. Expressed in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. Belongs to the Bcl-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q11.2-q12

Cellular Component: mitochondrial outer membrane; cytosol

Molecular Function: BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; Sertoli cell proliferation; spermatogenesis; negative regulation of apoptosis