Monoamine Oxidase B Recombinant Protein | MAO-B recombinant protein

Recombinant Human Monoamine Oxidase B

Cat. Num. AAA143591

• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: Monoamine Oxidase B; Recombinant Human Monoamine Oxidase B; MAO B Human; Monoamine Oxidase B Human Recombinant; Amine oxidase [flavin-containing] B; Monoamine oxidase type B; MAO-B; MAOB; MGC26382; MAO-B recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: MAO-B protein is supplied in 20mM Tris-HCl, pH 8.0, 250mM NaCl, 1mM EDTA and 50% glycerol.; Sterile Filtered clear solution.
• Sequence Length: 520

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.

Related Product Information for MAO-B recombinant protein

Description: MAO-B Human Recombinant produced in E Coli is single, a non-glycosylated, Polypeptide chain containing 488 amino acids fragment (2-489) corresponding to the cytoplasmic domain fragment of the mature protein, having a total molecular mass of 59.84kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The MAO-B is purified by proprietary chromatographic techniques.

Introduction: MAO-B is a member of the flavin monoamine oxidase family. MAO-B (Monoamine oxidase B) is a flavin-containing mitochondrial enzyme that catalyzes the oxidative deamination of biogenic and xenobiotic monoamines. MAO-B controls the metabolic degradation of catecholamines and serotonin in neural and other target tissues. MAO-B is located in platelets and in dopamine-secreting neurons in the brain. MAOB and MAOA genes have an imperative function in dopamine degradation. Benzylamine and phenylethylamine are preferentially degraded by MAOB. The MAOB gene is linked to autistic traits, empathy and Asperger syndrome. Amplified levels of MAO B are identified in the brain of Alzheimer's patients. High phenylethylamine levels in neonates as a result of low MAOB are consistent with phenylketonuria in newborns. Polymorphisms in MAO-B are connected to smoking behavior.

Product Categories/Family for MAO-B recombinant protein

Enzymes; Oxidase

NCBI and Uniprot Product Information

• NCBI GI #: 38202207
• NCBI GeneID: 4129
• NCBI Accession #: NP_000889.3
• NCBI GenBank Nucleotide #: NM_000898.4
• UniProt Accession #: P27338; Q7Z6S2; B2R6R3; B7Z5H3; D3DWC3
• Molecular Weight: 46,539 Da
• NCBI Official Full Name: amine oxidase
• NCBI Official Synonym Full Names: monoamine oxidase B
• NCBI Official Symbol: MAOB
• NCBI Protein Information: amine oxidase [flavin-containing] B; amine oxidase [flavin-containing] B; MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase
• UniProt Protein Name: Amine oxidase [flavin-containing] B
• UniProt Gene Name: MAOB
• UniProt Synonym Gene Names: MAO-B
• UniProt Entry Name: AOFB_HUMAN

NCBI Description

The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]

Uniprot Description

MAOB: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. Belongs to the flavin monoamine oxidase family.

Protein type: Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - glycine, serine and threonine; Membrane protein, integral; EC 1.4.3.4; Mitochondrial; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: mitochondrial envelope; mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; integral to membrane

Molecular Function: amine oxidase activity; protein homodimerization activity; FAD binding; electron carrier activity

Biological Process: response to drug; negative regulation of serotonin secretion; positive regulation of dopamine metabolic process; response to selenium ion; response to ethanol; substantia nigra development; dopamine catabolic process; response to toxin; xenobiotic metabolic process; response to lipopolysaccharide; hydrogen peroxide biosynthetic process; response to aluminum ion; response to corticosterone stimulus