Ubiquitin carboxyl-terminal hydrolase 64E (Ubp64E) Recombinant Protein | Ubp64E recombinant protein

Recombinant Drosophila melanogaster Ubiquitin carboxyl-terminal hydrolase 64E (Ubp64E), partial

• Gene Names: Usp47; BcDNA:LD12764; CG5486; D-Ubp-64E; D-UBP-64E; DmelCG5486; dUbp64; dUSP47; E(var)1; E(var)3-64E; E-var(3)64E; Q24574; UBP; ubp64; Ubp64; ubp64E; Ubp64E; UBP64E; Upd64E; usp47
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ubiquitin carboxyl-terminal hydrolase 64E (Ubp64E); Recombinant Drosophila melanogaster Ubiquitin carboxyl-terminal hydrolase 64E (Ubp64E); partial; Ubp64E recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,538

• Species: Drosophila melanogaster (Fruit fly)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 24658577
• NCBI GeneID: 38644
• NCBI Accession #: NP_523937.2
• NCBI GenBank Nucleotide #: NM_079213.4
• UniProt Accession #: Q24574; Q95TM9; Q9VRP1; A4V1I7
• Molecular Weight: 171,896 Da
• NCBI Official Full Name: ubiquitin specific protease 47, isoform B
• NCBI Official Synonym Full Names: Ubiquitin specific protease 47
• NCBI Official Symbol: Usp47
• NCBI Official Synonym Symbols: BcDNA:LD12764; CG5486; D-Ubp-64E; D-UBP-64E; DmelCG5486; dUbp64; dUSP47; E(var)1; E(var)3-64E; E-var(3)64E; Q24574; UBP; ubp64; Ubp64; ubp64E; Ubp64E; UBP64E; Upd64E; usp47
• NCBI Protein Information: CG5486 gene product from transcript CG5486-RD
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 47
• Protein Family: Ubiquitin carboxyl-terminal hydrolase
• UniProt Gene Name: Usp47

Uniprot Description

Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways (PubMed:10949024, PubMed:18160715, PubMed:26169834, PubMed:27552662). Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway (PubMed:27552662). Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev (PubMed:27552662). Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putative E3 ligases poe, Ufd4 and Kcmf1, which mediate the ubiquitination and proteasomal degradation of rl (PubMed:27552662). During eye development it may also act downstream of rl/MAPK to negatively regulate the Ras/MAPK signaling pathway by stabilizing the transcriptional repressor ttk and consequently inhibiting photoreceptor cell development (PubMed:18160715). This suggests that at least during eye development, it may act in both the positive and negative regulation of the Ras/MAPK signaling pathway to mediate the development of different cell types (PubMed:18160715, PubMed:27552662). Positively regulates border follicle cell migration during oogenesis by mediating the deubiquitination and stabilization of slbo (PubMed:10949024). In the wing disks it positively regulates wg signaling by stabilizing arm (PubMed:26169834). Has an effect on position-effect variegation (PubMed:8816485).