Inositol Monophosphatase Domain Containing 1 Active Protein | IMPAD1 active protein

Recombinant Human Inositol Monophosphatase Domain Containing 1, BioActive

Cat. Num. AAA141628

• Gene Names: IMPAD1; GPAPP; IMP 3; IMP-3; IMPA3
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Inositol Monophosphatase Domain Containing 1; Recombinant Human Inositol Monophosphatase Domain Containing 1; BioActive; IMPAD1 Active; IMPAD1 Human Active; Inositol Monophosphatase Domain Containing 1 Human Recombinant; Inositol monophosphatase 3; IMP 3; IMPase 3; EC 31325; EC 3137; Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase; Golgi-resident PAP phosphatase; gPAPP; Inositol monophosphatase domain-containing protein 1; Inositol-1(or 4)-monophosphatase 3; Myo-inositol monophosphatase A3; IMPAD1; IMPA3; GPAPP; IMP-3; IMPAD1 active protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: Sterile filtered colorless solution.; The IMPAD1 solution (0.25mg/ml) contains Phosphate-Buffered Saline (pH7.4).
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSGRFSLFG LGGEPGGGAA GPAAAADGGT VDLREMLAVS VLAAVRGGDE VRRVRESNVL HEKSKGKTRE GAEDKMTSGD VLSNRKMFYL LKTAFPSVQI NTEEHVDAAD QEVILWDHKI PEDILKEVTT PKEVPAESVT VWIDPLDATQ EYTEDLRKYV TTMVCVAVNG KPMLGVIHKP FSEYTAWAMV DGGSNVKARS SYNEKTPRIV VSRSHSGMVK QVALQTFGNQ TTIIPAGGAG YKVLALLDVP DKSQEKADLY IHVTYIKKWD ICAGNAILKA LGGHMTTLSG EEISYTGSDG IEGGLLASIR MNHQALVRKL PDLEKTGHK

• Biological Activity: Specific activity is >3300pmol/min/ug, and is defined as its ability to dephosphorylate adenosine 3'5'-diphosphate sodium slat at pH7.5, 25 degree C.
• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks.; Store, frozen at -20 degree C for longer periods of time.; For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).; Avoid multiple freeze-thaw cycles.

Related Product Information for IMPAD1 active protein

Inositol Monophosphatase Domain Containing 1 or IMPAD1 is a protein, part of the inositol monophosphatase group of proteins. The protein is found in Golgi apparatus and enhances phosphoadenosine phosphate hydrolysis to adenosine monophosphate. When Mutation in the IMPAD1 gene occurs leads to GRAPP type chondrodysplasia and therefore joint dislocations. On long arm chromosome 1 a pseudogene can be found.
IMPAD1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 349 amino acids (34-359 a.a.) and having a molecular mass of 37.6kDa. IMPAD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Categories/Family for IMPAD1 active protein

RECOMBINANT & NATURAL PROTEINS

NCBI and Uniprot Product Information

• NCBI GI #: 157388900
• NCBI GeneID: 54928
• NCBI Accession #: NP_060283.3
• NCBI GenBank Nucleotide #: NM_017813.4
• UniProt Accession #: Q9NX62; Q6NVY7
• Molecular Weight: 38,681 Da
• NCBI Official Full Name: inositol monophosphatase 3
• NCBI Official Synonym Full Names: inositol monophosphatase domain containing 1
• NCBI Official Symbol: IMPAD1
• NCBI Official Synonym Symbols: GPAPP; IMP 3; IMP-3; IMPA3
• NCBI Protein Information: inositol monophosphatase 3; Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase; IMPase 3; golgi-resident PAP phosphatase; inositol monophosphatase domain-containing protein 1; inositol-1(or 4)-monophosphatase 3; myo-inositol monophosphat
• UniProt Protein Name: Inositol monophosphatase 3
• Protein Family: Inositol monophosphatase
• UniProt Gene Name: IMPAD1
• UniProt Synonym Gene Names: IMPA3; IMP 3; IMPase 3; Golgi-resident PAP phosphatase; gPAPP
• UniProt Entry Name: IMPA3_HUMAN

NCBI Description

This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1. [provided by RefSeq, Dec 2011]

Uniprot Description

IMPAD1: May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Defects in IMPAD1 are the cause of chondrodysplasia with joint dislocations GPAPP type (CDP-GPAPP). A condition consisting of congenital joint dislocations, chondrodysplasia with short stature, micrognathia and cleft palate, and a distinctive face. Belongs to the inositol monophosphatase family.

Protein type: Membrane protein, integral; EC 3.1.3.25; Phosphatase (non-protein); EC 3.1.3.7

Chromosomal Location of Human Ortholog: 8q12.1

Cellular Component: Golgi apparatus; membrane; integral to membrane

Molecular Function: 3'-nucleotidase activity; metal ion binding; inositol-1(or 4)-monophosphatase activity; 3'(2'),5'-bisphosphate nucleotidase activity

Biological Process: chondroitin sulfate metabolic process; dephosphorylation; phosphoinositide phosphorylation; inositol biosynthetic process; embryonic digit morphogenesis; chondrocyte development; endochondral ossification; post-embryonic development

Disease: Chondrodysplasia With Joint Dislocations, Gpapp Type