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Retinoic Acid Receptor Responder 2 Recombinant Protein | RARRES2 recombinant protein

Recombinant Human Retinoic Acid Receptor Responder 2, HEK

Gene Names
RARRES2; TIG2; HP10433
Purity
>90.0% as determined by SDS-PAGE.
Synonyms
Retinoic Acid Receptor Responder 2; Recombinant Human Retinoic Acid Receptor Responder 2; HEK; Chemerin; TIG2; Tazarotene-induced gene 2 protein; Retinoic acid receptor responder protein 2; RAR-responsive protein TIG2; RARRES2; HP10433; RARRES2 Human; Retinoic Acid Receptor Responder 2 Human Recombinant; RARRES2 recombinant protein
Ordering
For Research Use Only!
Host
HEK293
Purity/Purification
>90.0% as determined by SDS-PAGE.
Form/Format
Sterile filtered colorless solution.
RARRES2 protein solution (0.5mg/ml) contains 10% glycerol & Phosphate buffered saline (pH7.4).
Sequence
Amino acid: ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFAFSHHH HHH.
Sequence Length
163
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Related Product Information for RARRES2 recombinant protein
Introduction: RARRES2 is a secreted chemotactic protein that initiates chemotaxis through the ChemR23 G protein-coupled seven-transmembrane domain ligand. RARRES2 is upregulated by the synthetic retinoid tazarotene and found in many tissues. RARRES2 acts as an adipokine and is truncated on both termini from the proprotein. RARRES2 is structurally related to the cathelicidin precursors, cystatin C and kininogens. RARRES2 promotes calcium mobilization and chemotaxis of immature dendritic cells and macrophages. RARRES2 is secreted as a precursor of little biological activity, which requires proteolytic cleavage of its COOH-terminal domain to be exchangeed into a potent and highly specific agonist of ChemR23.

Description: RARRES2 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (21-157 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 143 amino acids and having a molecular mass of 16.6kDa.RARRES2 shows multiple bands between 13.5-18kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
Product Categories/Family for RARRES2 recombinant protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
retinoic acid receptor responder protein 2
NCBI Official Synonym Full Names
retinoic acid receptor responder 2
NCBI Official Symbol
RARRES2
NCBI Official Synonym Symbols
TIG2; HP10433
NCBI Protein Information
retinoic acid receptor responder protein 2
UniProt Protein Name
Retinoic acid receptor responder protein 2
UniProt Gene Name
RARRES2
UniProt Synonym Gene Names
TIG2
UniProt Entry Name
RARR2_HUMAN

NCBI Description

This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014]

Uniprot Description

RARRES2: Inhibited in psoriatic lesions. Activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: extracellular matrix; extracellular region

Molecular Function: protein binding; receptor binding

Biological Process: positive regulation of chemotaxis; in utero embryonic development; brown fat cell differentiation; positive regulation of fat cell differentiation; positive regulation of protein amino acid phosphorylation; inflammatory response; retinoid metabolic process; chemotaxis; embryonic gut development; regulation of lipid catabolic process

Research Articles on RARRES2

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Product Notes

The RARRES2 rarres2 (Catalog #AAA141445) is a Recombinant Protein produced from HEK293 and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Amino acid: ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFAFSHHH HHH. It is sometimes possible for the material contained within the vial of "Retinoic Acid Receptor Responder 2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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