Hexokinase-4 Recombinant Protein | HK4 recombinant protein

Recombinant Human Hexokinase-4, Active

Cat. Num. AAA141359

• Gene Names: GCK; GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3
• Purity: >95% as determined by SDS-PAGE
• Synonyms: Hexokinase-4; Recombinant Human Hexokinase-4; Active; Hexokinase-4 Human Recombinant; Glucokinase; Glucokinase (Hexokinase 4); Hexokinase Type IV; HK IV; Maturity Onset Diabetes of The Young 2; ATP:D-Hexose 6-Phosphotransferase; Hexokinase D; Pancreatic Isozyme; Hexokinase-D; Hexokinase 4; GCK Human; HK4 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Sterile Filtered Colorless Solution; Protein solution (1mg/ml) contains 20 mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
• Sequence: LEETLLNTKL ETADLKWVTF PQVDGQWEEL SGLDEEQHSV RTYEVCDVQR APGQAHWLRT GWVPRRGAVH VYATLRFTML ECLSLPRAGRSCKETFTVFY YESDADTATA LTPAWMENPY IKVDTVAAEH LTRKRPGAEA TGKVNVKTLR LGPLSKAGFY LAFQDQGACM ALLSLHLFYK KCAQLTVNLT RFPETVPREL VVPVAGSCVV DAVPAPGPSP SLYCREDGQW AEQPVTGCSC APGFEAAEGN TKCRACAQGT FKPLSGEGSC QPCPANSHSN TIGSAVCQCR VGYFRARTDP RGAPCTTPPS APRSVVSRLN GSSLHLEWSA PLESGGREDL TYALRCRECR PGGSCAPCGG DLTFDPGPRD LVEPWVVVRG LRPDFTYTFE VTALNGVSSL ATGPVPFEPV NVTTDREVPP AVSDIRVTRS SPSSLSLAWA VPRAPSGAVL DYEVKYHEKG AEGPSSVRFL KTSENRAELR GLKRGASYLV QVRARSEAGY GPFGQEHHSQ TQLDESEGWR EQLAVEHHHH HH
• Sequence Length: 465

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.; For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze/thaw cycles.

Related Product Information for HK4 recombinant protein

Introduction: GCK is an enzyme that expedite the formation of glucose-6-phosphate for glucose by phosphorylation. Humans and other vertebrates have GCK in the cells of the pancreas and liver. In both organs, the enzyme has an important role in carbohydrate metabolism regulation by sensing sugar levels and acting according to the change in glucose levels, that can rise after a meal or fall during fasting. Mutations in the gene that codes for this enzyme can cause hypoglycemia or diabetes.

Description: GCK Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 485 amino acids (1-465 a.a) and having a molecular mass of 54.3kDa. GCK is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Categories/Family for HK4 recombinant protein

Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 547696
• NCBI GeneID: 2645
• UniProt Accession #: P35557
• NCBI Official Full Name: Glucokinase
• NCBI Official Synonym Full Names: glucokinase
• NCBI Official Symbol: GCK
• NCBI Official Synonym Symbols: GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3
• NCBI Protein Information: glucokinase
• UniProt Protein Name: Glucokinase
• Protein Family: Hexokinase
• UniProt Gene Name: GCK
• UniProt Synonym Gene Names: HK IV; HK4
• UniProt Entry Name: HXK4_HUMAN

NCBI Description

This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017]