Uniprot Description
E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle ().
Product Notes
The Rnf157 rnf157 (Catalog #
AAA1403705) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-685, Full length protein. The amino acid sequence is listed below: GALTSRQHAG VEEVDIPSNS VYRYPPKSGS YFASHFIMGG EKFDSTHPEG YLFGENSDLN FLGNRPVAFP YAAPPPQEPV KTLRSLINIR KDTLRLVKCA EEVKSHGEEA GKAKVHYNVE FTFDTDARVA ITIYYQATEE FQNGIASYIP KDNSLQSETV HYKRGVFQQF CLPSHTVDPS EWAEEELGFD LDREVYPLVV HAVVDEGDEY FGHCHVLLGT FEKHPDGTFC VKPLKQKQVV DGVSYLLQEI YGIENKYNTQ DSKVAEDDVS DNSAECVVCL SDVRDTLILP CRHLCLCNTC ADTLRYQANN CPICRLPFRA LLQIRAMRKK LGPLSPSSFN PIISSQTSDS EEHSSSENIP PGYEVVSLLE ALNGPLTSSP AVPPLHVLGD GHLSGMLPSY GSDGYLPPVR TLSPLDRLSD CNNQGLKLKK SLSKSISQNS SVLHEEEDER SCSESDTQLS QRLSVQHPEE GPDVTPESEN LTLSSSGAVD QSSCTGTPLS STISSPEDPA SSSLAQSVMS MASSQISTDT VSSMSGSYIA PGTEEEGEAL PSPRAASRAP SEGEETPAES PDSNFAGLPA GEQDAEGNDI IEEEDRSPVR EDGQRTCAFL GMECDNNNDF DVASVKALDN KLCSEVCLPG EWQCAEHELG GRRPSARPRS PRGGLGKEAS AFRIETVALP GTYV.
It is sometimes possible for the material contained within the vial of
"RING finger protein 157 (Rnf157), Recombinant Protein" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
any time and without notice. It is the responsibility of the customer to inform AAA Biotech
of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
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