Mouse Homer Homolog-1 Monoclonal Antibody | anti-HOMER1 antibody

Mouse Anti Human Homer Homolog-1

Cat. Num. AAA140270

• Gene Names: HOMER1; HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C
• Applications: ELISA, Western Blot
• Purity: HOMER1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Synonyms: Homer Homolog-1; Monoclonal Antibody; Mouse Anti Human Homer Homolog-1; HOMER1 Antibody; Mouse Anti Human; HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C; HOMER1; Homer protein homolog 1; anti-HOMER1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b heavy chain and kappa light chain
• Clone Number: PAT1F3AT
• Purity/Purification: HOMER1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Form/Format: 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
• Sequence Length: 177

• Applicable Applications for anti-HOMER1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: HOMER1 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ~ 2000. Recommended starting dilution is 1:1000.
• Immunogen: Anti-human HOMER1 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HOMER1 amino acids 1-354 purified from E Coli.
• Preparation and Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.; 12 months at -20 degree C. 1 month at 4 degree C.

Related Product Information for anti-HOMER1 antibody

Introduction: HOMER1 takes part in determining the apoptotic susceptibility to TRAIL. HOMER1 is a member of the Homer family of proteins that regulate signal transduction through, and the trafficking of, glutamate receptors, plus maintain and regulate extracellular glutamate levels in corticolimbic brain regions. The HOMER1 is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs).

Product Categories/Family for anti-HOMER1 antibody

Monoclonal/Polyclonal Antibodies; Monoclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 459215040
• NCBI GeneID: 9456
• NCBI Accession #: NP_001264007.1
• NCBI GenBank Nucleotide #: NM_001277078.1
• Molecular Weight: 19,861 Da
• NCBI Official Full Name: homer protein homolog 1 isoform 3
• NCBI Official Synonym Full Names: homer scaffolding protein 1
• NCBI Official Symbol: HOMER1
• NCBI Official Synonym Symbols: HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C
• NCBI Protein Information: homer protein homolog 1; homer homolog 1; homer, neuronal immediate early gene, 1; homer-1
• UniProt Protein Name: Homer protein homolog 1
• Protein Family: Homer protein
• UniProt Gene Name: HOMER1
• UniProt Synonym Gene Names: SYN47; Homer-1
• UniProt Entry Name: HOME1_HUMAN

NCBI Description

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]

Uniprot Description

HOMER1: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Belongs to the Homer family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q14.2

Cellular Component: postsynaptic membrane; costamere; cell soma; axon; apical part of cell; excitatory synapse; dendritic shaft; Z disc; cell junction

Molecular Function: identical protein binding; metabotropic glutatmate receptor binding; protein heterodimerization activity; type 5 metabotropic glutamate receptor binding; protein complex scaffold

Biological Process: skeletal muscle contraction; response to nicotine; circadian rhythm; synaptic transmission; positive regulation of signal transduction; chemical homeostasis within a tissue; behavioral response to cocaine; metabotropic glutamate receptor, phospholipase C activating pathway; skeletal muscle fiber development; response to calcium ion; positive regulation of calcium ion transport