Rat B220 Monoclonal Antibody | anti-B220 antibody
Rat Anti Mouse B220 (CD45R)
Gene Names
RPO21; RPB1; RPB220; SUA8
Purity
Ion exchange column.
Synonyms
B220; Monoclonal Antibody; Rat Anti Mouse B220 (CD45R); B220 Antibody; B220 (B cell specific isoform of CD45); Rat Anti-Mouse; LCA; PTPRC; LY5; CD45R; T200; GP180; PROTEIN-TYROSINE PHOSPHATASE; RECEPTOR-TYPE C; anti-B220 antibody
Host
Rat
Clonality
Monoclonal
Isotype
IgM
Clone Number
mB220
Purity/Purification
Ion exchange column.
Concentration
1mg/ml in PBS (after reconstitution). (varies by lot)
Sequence Length
1733
Reconstitution
Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Immunogen
Purified mouse LN B cells.
Antibody Properties
Staining antibody. For staining, use 10 ul/1,000,000 cells.
Available Conjugates
This antibody is only available as purified antibody.
Preparation and Storage
Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
Related Product Information for anti-B220 antibody
Introduction: B220 (CD45R) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.B220 (CD45R) is required for t-cell activation through the antigen receptor. The first ptpase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
Product Categories/Family for anti-B220 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
DNA-directed RNA polymerase II core subunit RPO21
NCBI Official Symbol
RPO21
NCBI Official Synonym Symbols
RPB1; RPB220; SUA8
NCBI Protein Information
DNA-directed RNA polymerase II core subunit RPO21
Research Articles on B220
Similar Products
Product Notes
The B220 (Catalog #AAA140040) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "B220, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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