Mouse Macrophage/Monocyte Chemotactic Protein-3/MARC Monoclonal Antibody | anti-MCP-3 antibody

Mouse Anti Human Macrophage/Monocyte Chemotactic Protein-3/MARC

Cat. Num. AAA140021

• Gene Names: CCL7; FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: Protein A.
• Synonyms: Macrophage/Monocyte Chemotactic Protein-3/MARC; Monoclonal Antibody; Mouse Anti Human Macrophage/Monocyte Chemotactic Protein-3/MARC; MCP 3 Antibody; Mouse Anti-Human; Small inducible cytokine A7; CCL7; Monocyte chemotactic protein 3; MCP-3; Monocyte chemoattractant protein 3; NC28; chemokine (C-C motif) ligand 7; FIC; MARC; MCP3; SCYA6; SCYA7; MGC138463; MGC138465; anti-MCP-3 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: YNR-HMCP3
• Purity/Purification: Protein A.
• Concentration: 1mg/ml in PBS (after reconstitution). (varies by lot)
• Sequence Length: 99

• Applicable Applications for anti-MCP-3 antibody: ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Direct ELISA, Western Blot, Immunoprecipitation.; In direct ELISA, using alkaline phosphatase goat anti-mouse Ig (Jackson Laboratories) 1:20,000 dilution will give 0.2 O.D.
• Reconstitution: Reconstitute with sterile H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
• Immunogen: r.Human MCP-3.
• Preparation and Storage: In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.; Antibody is shipped lyophilized at ambient temperature.

Related Product Information for anti-MCP-3 antibody

Introduction: Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates macrophagefunction. It is produced by certain tumor celllines and by macrophages. This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines and is most closely related to CCL2(previously called MCP1).

Product Categories/Family for anti-MCP-3 antibody

Monoclonal Antibodies; Anti-Human Chemokines; Monoclonal Antibodies; Anti Human Chemokine

NCBI and Uniprot Product Information

• NCBI GI #: 13435402
• NCBI GeneID: 6354
• NCBI Accession #: NP_006264.2
• NCBI GenBank Nucleotide #: NM_006273.3
• Molecular Weight: 11,200 Da
• NCBI Official Full Name: C-C motif chemokine 7
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 7
• NCBI Official Symbol: CCL7
• NCBI Official Synonym Symbols: FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7
• NCBI Protein Information: C-C motif chemokine 7; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; small inducible cytokine A7 (monocyte chemotactic protein 3); small-inducible cytokine A7
• UniProt Protein Name: C-C motif chemokine 7
• UniProt Gene Name: CCL7
• UniProt Synonym Gene Names: MCP3; SCYA6; SCYA7; MCP-3
• UniProt Entry Name: CCL7_HUMAN

NCBI Description

This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]

Uniprot Description

CCL7: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; CCR1 chemokine receptor binding; chemokine activity; CCR2 chemokine receptor binding

Biological Process: cellular calcium ion homeostasis; regulation of cell shape; monocyte chemotaxis; cell-cell signaling; eosinophil chemotaxis; response to gamma radiation; immune response; cytoskeleton organization and biogenesis; signal transduction; chemotaxis; inflammatory response; positive regulation of cell migration