Fibrinogen gamma chain (Fgg) Recombinant Protein | Fgg recombinant protein

Recombinant Mouse Fibrinogen gamma chain (Fgg)

Cat. Num. AAA1394506

• Gene Names: Fgg; AI256424; 3010002H13Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Fibrinogen gamma chain (Fgg); Recombinant Mouse Fibrinogen gamma chain (Fgg); Fgg recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 26-436, full length protein
• Sequence: YVATRDNCCILDERFGSFCPTTCGIADFLSSYQTDVDNDLRTLEDILFRAENRTTEAKELIKAIQVYYNPDQPPKPGMIDSATQKSKKMVEEIVKYEALLLTHETSIRYLQEIYNSNNQKITNLKQKVAQLEAQCQEPCKDSVQIHDTTGKDCQEIANKGAKESGLYFIRPLKAKQQFLVYCEIDGSGNGWTVLQKRIDGSLDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISMQSTIPYALRIQLKDWNGRTSTADYAMFRVGPESDKYRLTYAYFIGGDAGDAFDGYDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYHQGGTYSKSSTTNGFDDGIIWATWKSRWYSMKETTMKIIPFNRLSIGEGQQHHMGGSKQAGDV
• Sequence Length: 411

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Fgg recombinant protein

This protein is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 19527078
• NCBI GeneID: 99571
• NCBI Accession #: NP_598623.1
• NCBI GenBank Nucleotide #: NM_133862.2
• UniProt Accession #: Q8VCM7; Q8WUR3; Q91ZP0
• Molecular Weight: 49,391 Da
• NCBI Official Full Name: fibrinogen gamma chain isoform 1
• NCBI Official Synonym Full Names: fibrinogen gamma chain
• NCBI Official Symbol: Fgg
• NCBI Official Synonym Symbols: AI256424; 3010002H13Rik
• NCBI Protein Information: fibrinogen gamma chain
• UniProt Protein Name: Fibrinogen gamma chain
• Protein Family: Fibrinogen
• UniProt Gene Name: Fgg

NCBI Description

This gene encodes the gamma subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Mice lacking the encoded protein did not possess detectable amounts of plasma fibrinogen. Pregnant mice lacking the encoded protein die due to heavy bleeding during delivery. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]

Uniprot Description

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (). Fibrin has a major function in hemostasis as one of the primary components of blood clots (). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769). Maternal fibrinogen is essential for successful pregnancy (). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (). May also facilitate the immune response via both innate and T-cell mediated pathways ().