Histone acetyltransferase KAT5 (Kat5) Recombinant Protein | Kat5 recombinant protein

Recombinant Rat Histone acetyltransferase KAT5 (Kat5)

Cat. Num. AAA1394063

• Gene Names: Kat5; Tip60; Htatip; Htatip1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Histone acetyltransferase KAT5 (Kat5); Recombinant Rat Histone acetyltransferase KAT5 (Kat5); Kat5 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-513, full length protein
• Sequence: MAEVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGSARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW
• Sequence Length: 513

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Kat5 recombinant protein

This protein belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 54607159
• NCBI GeneID: 192218
• NCBI Accession #: NP_001005872.1
• NCBI GenBank Nucleotide #: NM_001005872.1
• UniProt Accession #: Q99MK2; Q5XI16
• Molecular Weight: 53,093 Da
• NCBI Official Full Name: histone acetyltransferase KAT5
• NCBI Official Synonym Full Names: lysine acetyltransferase 5
• NCBI Official Symbol: Kat5
• NCBI Official Synonym Symbols: Tip60; Htatip; Htatip1
• NCBI Protein Information: histone acetyltransferase KAT5
• UniProt Protein Name: Histone acetyltransferase KAT5
• Protein Family: Histone acetyltransferase
• UniProt Gene Name: Kat5
• UniProt Synonym Gene Names: Htatip; Tip60; Tip60b; Tip60

NCBI Description

human homolog facilitates Myc-induced histone acetylation [RGD, Feb 2006]

Uniprot Description

Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity. Acetylates RAN at 'Lys-134' ().