Nuclear factor NF-kappa-B p110 subunit (Rel) Recombinant Protein | Rel recombinant protein

Recombinant Drosophila melanogaster Nuclear factor NF-kappa-B p110 subunit (Rel), partial

• Gene Names: Rel; CG11992; DmelCG11992; ird; ird4; l(3)neo36; NF-kappaB; NFkappaB; rel; REL; Rel-p110; Rel/NF-kappaB; RelA; RELI; relish
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Nuclear factor NF-kappa-B p110 subunit (Rel); Recombinant Drosophila melanogaster Nuclear factor NF-kappa-B p110 subunit (Rel); partial; Rel recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 859

• Species: Drosophila melanogaster (Fruit fly)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 17137094
• NCBI GeneID: 41087
• NCBI Accession #: NP_477094.1
• NCBI GenBank Nucleotide #: NM_057746.4
• UniProt Accession #: Q94527; Q9U435; Q9U436; Q9U437; Q9U438; Q9U439; Q9U440; Q9U6H3; Q9U6H4; Q9U6H5; Q9VHI0; A4V2K3
• Molecular Weight: 97,894 Da
• NCBI Official Full Name: relish, isoform A
• NCBI Official Synonym Full Names: Relish
• NCBI Official Symbol: Rel
• NCBI Official Synonym Symbols: CG11992; DmelCG11992; ird; ird4; l(3)neo36; NF-kappaB; NFkappaB; rel; REL; Rel-p110; Rel/NF-kappaB; RelA; RELI; relish
• NCBI Protein Information: CG11992 gene product from transcript CG11992-RA
• UniProt Protein Name: Nuclear factor NF-kappa-B p110 subunit
• Protein Family: Nuclear factor
• UniProt Gene Name: Rel

Uniprot Description

Plays a key role in the humoral immune response (PubMed:8816802, PubMed:10619029, PubMed:11269501, PubMed:11872802, PubMed:22022271). Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes (PubMed:11269501). I-kappa-B kinase complex (ird5 and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation (PubMed:11872802, PubMed:11018014). Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition (PubMed:25477468). May be part of a NF-kappa-B and Tollo signaling cascade that regulates development of the peripheral nervous system (PubMed:18000549). Possibly post-transcriptionally regulates the neuron-specific genes sc and ase, by promoting the rapid turnover of their transcripts in the wing imaginal disk (PubMed:18000549).