Epithelial discoidin domain-containing receptor 1 (Ddr1) Recombinant Protein | Ddr1 recombinant protein

Recombinant Rat Epithelial discoidin domain-containing receptor 1 (Ddr1), partial

Cat. Num. AAA1357364

• Gene Names: Ddr1; Cak; Drd1; PTK3D
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Epithelial discoidin domain-containing receptor 1 (Ddr1); Recombinant Rat Epithelial discoidin domain-containing receptor 1 (Ddr1); partial; Ddr1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 22-414
• Sequence: DMKGHFDPA KCRYALGMQD RTIPDSDISV SSSWSDSTAA RHSRLESSDG DGAWCPAGPV FPKEEEYLQV DLRRLHLVAL VGTQGRHAGG LGKEFSRSYR LRYSRDGRRW MDWKDRWGQE VISGNEDPGG VVLKDLGPPM VARLVRFYPR ADRVMSVCLR VELYGCLWRD GLLSYTAPVG QTMQLSEMVY LNDSTYDGYT AGGLQYGGLG QLADGVVGLD DFRQSQELRV WPGYDYVGWS NHSFPSGYVE MEFEFDRLRS FQTMQVHCNN MHTLGARLPG GVECRFKRGP AMAWEGEPVH HALGGSLGDP RARAISVPLG GHVGRFLQCR FLFAGPWLLF SEISFISDVV NDSSDTFPPA PWWPPGPPPT NFSSLELEPR GQQPVAKAEG SPTA
• Sequence Length: 393

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Ddr1 recombinant protein

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. This protein is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 2497563
• NCBI GeneID: 25678
• UniProt Accession #: Q63474
• Molecular Weight: 101,165 Da
• NCBI Official Full Name: Epithelial discoidin domain-containing receptor 1
• NCBI Official Synonym Full Names: discoidin domain receptor tyrosine kinase 1
• NCBI Official Symbol: Ddr1
• NCBI Official Synonym Symbols: Cak; Drd1; PTK3D
• NCBI Protein Information: epithelial discoidin domain-containing receptor 1
• UniProt Protein Name: Epithelial discoidin domain-containing receptor 1
• Protein Family: Epithelial discoidin domain-containing receptor
• UniProt Gene Name: Ddr1
• UniProt Synonym Gene Names: Eddr1; Ptk3; Epithelial discoidin domain receptor 1

NCBI Description

protein tyrosine kinase that may play a role in nervous system development [RGD, Feb 2006]

Uniprot Description

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing ().