Inhibitory monoclonal antibody to human prorenin, clone 4B5-E3 Monoclonal Antibody | anti-REN antibody
Inhibitory monoclonal antibody to human prorenin, clone 4B5-E3
NCBI and Uniprot Product Information
NCBI Description
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
Uniprot Description
REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide; Protease; EC 3.4.23.15
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: extracellular space; cytoplasm; extracellular region; plasma membrane
Molecular Function: peptidase activity; insulin-like growth factor receptor binding; aspartic-type endopeptidase activity; receptor binding
Biological Process: response to cAMP; hormone-mediated signaling; renin-angiotensin regulation of aldosterone production; cell maturation; drinking behavior; male gonad development; response to lipopolysaccharide; proteolysis; angiotensin maturation; cellular protein metabolic process; regulation of MAPKKK cascade; beta-amyloid metabolic process; regulation of blood pressure; mesonephros development; kidney development
Disease: Renal Tubular Dysgenesis; Hyperuricemic Nephropathy, Familial Juvenile, 2
Research Articles on REN
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Product Notes
The REN ren (Catalog #AAA135012) is an Antibody produced from Host: Mouse; Source: Hybridoma cell culture and is intended for research purposes only. The product is available for immediate purchase. The Inhibitory monoclonal antibody to human prorenin, clone 4B5-E3 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Inhibitory monoclonal antibody to human prorenin, clone 4B5-E3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), BL. Researchers should empirically determine the suitability of the REN ren for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Inhibitory monoclonal antibody to human prorenin, clone 4B5-E3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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