Hamster Arachidonate 5-Lipoxygenase ELISA Kit | ALOX-5 elisa kit
Hamster Arachidonate 5-Lipoxygenase ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Catalytic activity: Arachidonate + O2 = leukotriene A4 + H2O.
Cofactor: Binds 1 iron ion per subunit
By similarity.Binds 2 calcium ions per subunit
By similarity.
Pathway: Lipid metabolism; leukotriene A4 biosynthesis.
Subunit structure: Interacts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and efficient catalytic activity
By similarity.
Subcellular location: Cytoplasm
By similarity. Nucleus matrix
By similarity. Nucleus membrane; Peripheral membrane protein
By similarity. Note: Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-271. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association
By similarity.
Post-translational modification: Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-271 prevents export from the nucleus
By similarity.
Sequence similarities: Belongs to the lipoxygenase family.Contains 1 lipoxygenase domain.Contains 1 PLAT domain.
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Product Notes
The Hamster ALOX-5 alox5 (Catalog #AAA013475) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA013475 ELISA Kit recognizes Hamster ALOX-5. It is sometimes possible for the material contained within the vial of "Arachidonate 5-Lipoxygenase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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