WD repeat-containing protein 81 (Wdr81) Recombinant Protein | Wdr81 recombinant protein

Recombinant Mouse WD repeat-containing protein 81 (Wdr81) , partial

• Gene Names: Wdr81; nur5; Gm883; BC054822; mFLJ00182
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: WD repeat-containing protein 81 (Wdr81); Recombinant Mouse WD repeat-containing protein 81 (Wdr81); partial; Wdr81 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,874

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 242118003
• NCBI GeneID: 192652
• NCBI Accession #: NP_620400.2
• NCBI GenBank Nucleotide #: NM_138950.2
• UniProt Accession #: Q5ND34; Q3TA90; Q3TUS9; Q6KAR1; G5E8V0
• Molecular Weight: 205,633 Da
• NCBI Official Full Name: WD repeat-containing protein 81
• NCBI Official Synonym Full Names: WD repeat domain 81
• NCBI Official Symbol: Wdr81
• NCBI Official Synonym Symbols: nur5; Gm883; BC054822; mFLJ00182
• NCBI Protein Information: WD repeat-containing protein 81
• UniProt Protein Name: WD repeat-containing protein 81
• Protein Family: WD repeat-containing protein
• UniProt Gene Name: Wdr81

Uniprot Description

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (). May also be involved in maintenance of normal mitochondrial structure and organization (PubMed:23595742).